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Synonyms
- Anti-ENA
- Anti-RNP
- Anti-Sm
Test Includes
Semiquantitative result of IgG class antibodies
Expected Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Hemolysis; icterus; lipemia; bacterial contamination
Test Details
Use
Detect antibodies associated with SLE and mixed connective tissue disease. Anti-Sm is highly specific for SLE. Anti-RNP is found with a variety of rheumatoid diseases with high titers associated mainly with MCTD.
Methodology
Multiplex flow immunoassay
Reference Interval
0.0−0.9 AI
Additional Information
Antibodies that produce a speckled ANA pattern are usually directed against extractable nucleoprotein complexes found in the nucleus and/or cytoplasm of substrate cells. Included in this group of antigens are RNP, Sm, SS-A, SS-B, Scl-70, and Jo-1.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 006338 | Antiextractable Nuclear Ag | 000000 | ||||
| 006338 | Antiextractable Nuclear Ag | 016354 | RNP Antibodies | AI | 29374-6 | |
| 006338 | Antiextractable Nuclear Ag | 016362 | Smith Antibodies | AI | 11090-8 |
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