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Iron Deficiency Anemia Cascade With Complete Blood Count (CBC) With Differential

Test Number 004800
Test number copied
CPT 85025

Test Details

Methodology

See individual test components.

Result Turnaround Time

Within 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Iron Deficiency Anemia Cascade White Paper

Use

This test is used to determine iron deficiency anemia.

Special Instructions

Note special reflexing: If Hemoglobin (Hb) [005041] is low, test will reflex to Ferritin [004598]. If Ferritin is normal, test will reflex to Iron and Total Iron-binding Capacity (TIBC) [001321]. Depending on results of Iron and TIBC, test may reflex to Soluble Transferrin Receptor [143305], all at an additional charge or CPT code.

Specimen Requirements

Specimen

Serum and whole blood

Volume

4 mL serum and 4 mL whole blood (fill tube to capacity)

Minimum Volume

Serum: 2 mL

Whole blood: 0.5 mL or 500 µL for pediatric microtainer capillary tubes; venous tube collection: fill tube to capacity

Container

Gel-barrier tube and lavender-top (EDTA) tube

Collection Instructions

Serum: Separate serum from cells within 45 minutes of collection.

Lavender-top: Invert tube 8 to 10 times immediately after tube is filled at the time of collection.

Stability Requirements

Temperature

Period

Room temperature

Serum: 14 days

Whole blood: 1 day

Refrigerated

Serum: 14 days

Whole blood: 3 days

Frozen

Serum: 14 days

Whole blood: Unstable

Storage Instructions

Maintain one serum and lavender-top tube at room temperature. Refrigerate one serum transport tube.

Causes for Rejection

Serum: Hemolysis; specimen clotted; improper labeling; EDTA, yellow-top tube, citrate or oxalate plasma specimen

Whole blood: Hemolysis; clotted specimen; specimen drawn in any anticoagulant other than EDTA; specimen diluted or contaminated with IV fluid; tube not filled with minimum volume; improper labeling; transfer tubes with whole blood; specimen received with plasma removed (plasma is used for other testing)

References

Baillie FJ, Morrison AE, Fergus I. Soluble transferrin receptor: a discriminating assay for iron deficiency. Clin Lab Haematol. 2003 Dec;25(6):353-357.14641138
Camaschella C. Iron deficiency: new insights into diagnosis and treatment. Hematology Am Soc Hematol Educ Program. 2015;2015:8-13.26637694
Cappellini MD, Musallam KM, Taher AT. Iron deficiency anaemia revisited. J Intern Med. 2020 Feb;287(2):153-170.31665543
Daru J, Allotey J, Pea-Rosas JP, Khan KS. Serum ferritin thresholds for the diagnosis of iron deficiency in pregnancy: a systematic review. Transfus Med. 2017 Jun;27(3):167-174.28425182
Farrington DK, Sang Y, Grams ME, et al. Anemia Prevalence, Type, and Associated Risks in a Cohort of 5.0 Million Insured Patients in the United States by Level of Kidney Function. Am J Kidney Dis. 2023 Feb;81(2):201-209.e1. Epub 22 Sep 28.36181996
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ. Iron deficiency anaemia: pathophysiology, assessment practical management. BMJ Open Gastroenterol. 2022 Jan;9(1):e000759.34996762

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
004800 Iron Def Anemia Cas.+CBC/D/Plt 005025 WBC x10E3/uL 6690-2
004800 Iron Def Anemia Cas.+CBC/D/Plt 005033 RBC x10E6/uL 789-8
004800 Iron Def Anemia Cas.+CBC/D/Plt 005041 Hemoglobin g/dL 718-7
004800 Iron Def Anemia Cas.+CBC/D/Plt 005058 Hematocrit % 4544-3
004800 Iron Def Anemia Cas.+CBC/D/Plt 015065 MCV fL 787-2
004800 Iron Def Anemia Cas.+CBC/D/Plt 015073 MCH pg 785-6
004800 Iron Def Anemia Cas.+CBC/D/Plt 015081 MCHC g/dL 786-4
004800 Iron Def Anemia Cas.+CBC/D/Plt 105007 RDW % 788-0
004800 Iron Def Anemia Cas.+CBC/D/Plt 015172 Platelets x10E3/uL 777-3
004800 Iron Def Anemia Cas.+CBC/D/Plt 015107 Neutrophils % 770-8
004800 Iron Def Anemia Cas.+CBC/D/Plt 015123 Lymphs % 736-9
004800 Iron Def Anemia Cas.+CBC/D/Plt 015131 Monocytes % 5905-5
004800 Iron Def Anemia Cas.+CBC/D/Plt 015149 Eos % 713-8
004800 Iron Def Anemia Cas.+CBC/D/Plt 015156 Basos % 706-2
004800 Iron Def Anemia Cas.+CBC/D/Plt 115398 Immature Cells N/A
004800 Iron Def Anemia Cas.+CBC/D/Plt 015909 Neutrophils (Absolute) x10E3/uL 751-8
004800 Iron Def Anemia Cas.+CBC/D/Plt 015917 Lymphs (Absolute) x10E3/uL 731-0
004800 Iron Def Anemia Cas.+CBC/D/Plt 015925 Monocytes(Absolute) x10E3/uL 742-7
004800 Iron Def Anemia Cas.+CBC/D/Plt 015933 Eos (Absolute) x10E3/uL 711-2
004800 Iron Def Anemia Cas.+CBC/D/Plt 015941 Baso (Absolute) x10E3/uL 704-7
004800 Iron Def Anemia Cas.+CBC/D/Plt 015108 Immature Granulocytes % 71695-1
004800 Iron Def Anemia Cas.+CBC/D/Plt 015911 Immature Grans (Abs) x10E3/uL 53115-2
004800 Iron Def Anemia Cas.+CBC/D/Plt 015945 NRBC % 58413-6
004800 Iron Def Anemia Cas.+CBC/D/Plt 015180 Hematology Comments: 18314-5
004800 Iron Def Anemia Cas.+CBC/D/Plt 004799 Iron Def Anemia Casc N/A
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code005025
Result Code NameWBC
UofMx10E3/uL
Result LOINC6690-2
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code005033
Result Code NameRBC
UofMx10E6/uL
Result LOINC789-8
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code005041
Result Code NameHemoglobin
UofMg/dL
Result LOINC718-7
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code005058
Result Code NameHematocrit
UofM%
Result LOINC4544-3
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015065
Result Code NameMCV
UofMfL
Result LOINC787-2
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015073
Result Code NameMCH
UofMpg
Result LOINC785-6
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015081
Result Code NameMCHC
UofMg/dL
Result LOINC786-4
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code105007
Result Code NameRDW
UofM%
Result LOINC788-0
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015172
Result Code NamePlatelets
UofMx10E3/uL
Result LOINC777-3
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015107
Result Code NameNeutrophils
UofM%
Result LOINC770-8
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015123
Result Code NameLymphs
UofM%
Result LOINC736-9
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015131
Result Code NameMonocytes
UofM%
Result LOINC5905-5
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015149
Result Code NameEos
UofM%
Result LOINC713-8
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015156
Result Code NameBasos
UofM%
Result LOINC706-2
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code115398
Result Code NameImmature Cells
UofM
Result LOINCN/A
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015909
Result Code NameNeutrophils (Absolute)
UofMx10E3/uL
Result LOINC751-8
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015917
Result Code NameLymphs (Absolute)
UofMx10E3/uL
Result LOINC731-0
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015925
Result Code NameMonocytes(Absolute)
UofMx10E3/uL
Result LOINC742-7
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015933
Result Code NameEos (Absolute)
UofMx10E3/uL
Result LOINC711-2
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015941
Result Code NameBaso (Absolute)
UofMx10E3/uL
Result LOINC704-7
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015108
Result Code NameImmature Granulocytes
UofM%
Result LOINC71695-1
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015911
Result Code NameImmature Grans (Abs)
UofMx10E3/uL
Result LOINC53115-2
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015945
Result Code NameNRBC
UofM%
Result LOINC58413-6
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code015180
Result Code NameHematology Comments:
UofM
Result LOINC18314-5
Order Code004800
Order Code NameIron Def Anemia Cas.+CBC/D/Plt
Order Loinc
Result Code004799
Result Code NameIron Def Anemia Casc
UofM
Result LOINCN/A
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115400 Bands % 35332-6
Reflex 1
Order Code115399
Order NameImmature Cells
Result Code115400
Result NameBands
UofM%
Result LOINC35332-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115401 Metamyelocytes % 28541-1
Reflex 1
Order Code115399
Order NameImmature Cells
Result Code115401
Result NameMetamyelocytes
UofM%
Result LOINC28541-1
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115403 Myelocytes % 26498-6
Reflex 1
Order Code115399
Order NameImmature Cells
Result Code115403
Result NameMyelocytes
UofM%
Result LOINC26498-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115404 Promyelocytes % 26498-6
Reflex 1
Order Code115399
Order NameImmature Cells
Result Code115404
Result NamePromyelocytes
UofM%
Result LOINC26498-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115405 Blasts/blast like cells % 26498-6
Reflex 1
Order Code115399
Order NameImmature Cells
Result Code115405
Result NameBlasts/blast like cells
UofM%
Result LOINC26498-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115406 Megakaryocytes % 19252-6
Reflex 1
Order Code115399
Order NameImmature Cells
Result Code115406
Result NameMegakaryocytes
UofM%
Result LOINC19252-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115265 Other, Lineage Uncertain % 55433-7
Reflex 1
Order Code115399
Order NameImmature Cells
Result Code115265
Result NameOther, Lineage Uncertain
UofM%
Result LOINC55433-7
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004801 Ferritin 004598 Ferritin ng/mL 2276-4
Reflex 1
Order Code004801
Order NameFerritin
Result Code004598
Result NameFerritin
UofMng/mL
Result LOINC2276-4
Reflex Table for Iron Def Anemia Casc
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004809 Comment: 004809 Comment: N/A
Reflex 1
Order Code004809
Order NameComment:
Result Code004809
Result NameComment:
UofM
Result LOINCN/A