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Immunoglobulin E, Total

CPT

82785

Synonyms
  • IgE

Test Details

Methodology

Thermo Fisher ImmunoCAP®

Result Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Use

Evaluate immunoglobulin status in possible atopic disease

Limitations

Normal IgE levels do not exclude allergic phenomena.

Footnotes

1. Dolen WK. The diagnostic allergy laboratory. In: Rose NR, Hamilton RG, Detrick B, eds. Manual of Clinical Laboratory Immunology. 6th ed. Washington, DC: ASM Press; 2002:883-890.
2. Zeiss RC, Pruzansky JJ. Immunology of IgE-mediated and other hypersensitivity states. In Grammar LC, Greenberger PA, eds. Patterson's Allergic Diseases. 6th ed. Hagerstown, Md: Lippincott Williams and Wilkins;2002:43-54.

Custom Additional Information

The concentration of IgE in serum of normal individuals typically represents <0.001% of the total immunoglobulins present.1,2 Immunoglobulins of the IgE class play an important role in mediating the atopic reactions that occur when sensitive individuals are exposed to allergens. IgE has a structure that is similar to other immunoglobulins in that it consists of four chains: two light chains and two heavy chains.1 The heavy chains for each IgE molecule contain a variable region that accounts for antigen specificity. Since IgE myeloma is extremely rare, the clinical utility of measuring IgE levels generally involves its role as the mediator of the allergic response. The majority of IgE molecules in serum are bound to the surface of mast cells and basophilic granulocytes. The interaction of allergens with the cell-bound allergen-specific IgE causes these cells to release histamines and other vasoactive substances, thereby initiating the allergic reaction. Approximately 50% of individuals with allergic rhinitis or asthma will have elevated levels of IgE;1 however, a large number of individuals with allergy and elevated levels of IgE to specific allergens will have normal levels of total IgE. Studies have indicated that total IgE levels are often elevated in patients with atopic dermatitis and the concentration of IgE tends to correlate with severity of eczema.1 Total IgE levels can also be elevated in patients with parasitic infections, allergic bronchopulmonary aspergillosis, or immunodeficiency.1,2

Specimen Requirements

Specimen

Serum

Volume

0.8 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection Instructions

If a red-top tube is used, transfer separated serum to a plastic transport tube.

Stability Requirements

TemperaturePeriod
Room temperature14 days
Refrigerated14 days
Frozen60 days
Freeze/thaw cyclesStable x3

Reference Range

AgeMaleFemale
1 to 30 daysNot establishedNot established
1 to 5 months1–300–16
6 months2–521–24
7 to 11 months2–822–82
1 year3–2002–100
2 to 3 years6–3664–227
4 to 6 years14–7106–455
7 to 9 years19–89312–708
10 years22–105512–708
11 years22–105512–796
12 years16–81012–796
13 years19–8939–681
14 to 15 years20–7989–681
16 years18–6289–472
17 to 100 years6–4956–495

Storage Instructions

Room temperature

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
002170 Immunoglobulin E, Total 19113-0 002173 Immunoglobulin E, Total IU/mL 19113-0
Order Code002170
Order Code NameImmunoglobulin E, Total
Order Loinc19113-0
Result Code002173
Result Code NameImmunoglobulin E, Total
UofMIU/mL
Result LOINC19113-0