Test Details
Methodology
Thermo Fisher ImmunoCAP®
Result Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Evaluate immunoglobulin status in possible atopic disease
Limitations
Normal IgE levels do not exclude allergic phenomena.
Footnotes
Custom Additional Information
The concentration of IgE in serum of normal individuals typically represents <0.001% of the total immunoglobulins present.1,2 Immunoglobulins of the IgE class play an important role in mediating the atopic reactions that occur when sensitive individuals are exposed to allergens. IgE has a structure that is similar to other immunoglobulins in that it consists of four chains: two light chains and two heavy chains.1 The heavy chains for each IgE molecule contain a variable region that accounts for antigen specificity. Since IgE myeloma is extremely rare, the clinical utility of measuring IgE levels generally involves its role as the mediator of the allergic response. The majority of IgE molecules in serum are bound to the surface of mast cells and basophilic granulocytes. The interaction of allergens with the cell-bound allergen-specific IgE causes these cells to release histamines and other vasoactive substances, thereby initiating the allergic reaction. Approximately 50% of individuals with allergic rhinitis or asthma will have elevated levels of IgE;1 however, a large number of individuals with allergy and elevated levels of IgE to specific allergens will have normal levels of total IgE. Studies have indicated that total IgE levels are often elevated in patients with atopic dermatitis and the concentration of IgE tends to correlate with severity of eczema.1 Total IgE levels can also be elevated in patients with parasitic infections, allergic bronchopulmonary aspergillosis, or immunodeficiency.1,2
Specimen Requirements
Specimen
Serum
Volume
0.8 mL
Minimum Volume
0.3 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Stability Requirements
Temperature | Period |
---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
Age | Male | Female |
---|---|---|
1 to 30 days | Not established | Not established |
1 to 5 months | 1–30 | 0–16 |
6 months | 2–52 | 1–24 |
7 to 11 months | 2–82 | 2–82 |
1 year | 3–200 | 2–100 |
2 to 3 years | 6–366 | 4–227 |
4 to 6 years | 14–710 | 6–455 |
7 to 9 years | 19–893 | 12–708 |
10 years | 22–1055 | 12–708 |
11 years | 22–1055 | 12–796 |
12 years | 16–810 | 12–796 |
13 years | 19–893 | 9–681 |
14 to 15 years | 20–798 | 9–681 |
16 years | 18–628 | 9–472 |
17 to 100 years | 6–495 | 6–495 |
Storage Instructions
Room temperature
LOINC® Map
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
002170 | Immunoglobulin E, Total | 19113-0 | 002173 | Immunoglobulin E, Total | IU/mL | 19113-0 |
Order Code | 002170 | |||||
Order Code Name | Immunoglobulin E, Total | |||||
Order Loinc | 19113-0 | |||||
Result Code | 002173 | |||||
Result Code Name | Immunoglobulin E, Total | |||||
UofM | IU/mL | |||||
Result LOINC | 19113-0 |