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Test Includes
Creatinine, serum; eGFR calculation
Expected Turnaround Time
Within 1 day
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum (preferred) or plasma
Volume
1 mL
Minimum Volume
0.7 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube, gel-barrier tube, or green-top (lithium heparin) tube. Do not use oxalate, EDTA, or citrate plasma.
Collection
Separate serum or plasma from cells within 45 minutes of collection.
Storage Instructions
Maintain specimen at room temperature.1
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Hemolysis; improper labeling
Test Details
Use
A renal function test used in eGFR calculation.2
High creatinine: Renal diseases and insufficiency with decreased glomerular filtration, urinary tract obstruction, reduced renal blood flow including congestive heart failure, shock, and dehydration; rhabdomyolysis can cause elevated serum creatinine. Low creatinine: Small stature, debilitation, decreased muscle mass; some complex cases of severe hepatic disease can cause low serum creatinine levels. In advanced liver disease, low creatinine may result from decreased hepatic production of creatinine and inadequate dietary protein as well as reduced muscle mass.3
Limitations
With reduced renal blood flow, creatinine rises less quickly than urea nitrogen. Concentration of creatinine only becomes abnormal when about half or more of the nephrons have stopped functioning in chronic progressive renal disease. Antibiotics containing cephalosporin lead to significant false-positive values if samples are drawn within four hours of a dose.4 With severe renal disease, creatinine is not reliable in the presence of cefoxitin therapy. There is less interference reported from the cephalosporins cephalothin, cephaloridine, cephadrine sodium, and cephaloglycin dihydrate. Lipemia, hemolysis, and bilirubin may interfere.5,6
Interfering Endogenous Substances7 | Deviations | Degree of Interference |
|---|---|---|
Pyruvate (serum/plasma) | >2.6 mg/dL | +12.8% |
Glucose (serum/plasma) | >450 mg/dL | +16% |
Ascorbic acid (serum/plasma) | >88 mg/dL | -10.1% |
Urea (urine) | >12612 mg/dL | -11.0% |
Methodology
Kinetic Jaffe
Reference Interval
See table.
Age | Female* (mg/dL) | Male (mg/dL) |
|---|---|---|
*Labcorp internal studies. | ||
Age/sex regardless | 0.57−1.00 | 0.76−1.27 |
<2 m | 0.44−1.19 | 0.44−1.19 |
2 to 11 m | 0.17−1.18 | 0.17−1.18 |
1 to <3 y | 0.19−0.42 | 0.19−0.42 |
3 to <5 y | 0.26−0.51 | 0.26−0.51 |
5 to <7 y | 0.30−0.59 | 0.30−0.59 |
7 to <9 y | 0.37−0.62 | 0.37−0.62 |
9 to <11 y | 0.39−0.70 | 0.39−0.70 |
11 to <13 y | 0.42−0.75 | 0.42−0.75 |
13 to <15 y | 0.49−0.90 | 0.49−0.90 |
≥15 y | 0.57−1.00 | 0.76−1.27 |
Footnotes
1. Labcorp internal studies.
2. Levey AS, Stevens LA, Schmid CH; CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009 May 5; 150(9):604-612.19414839
3. Takabatake T, Ohta H, Ishida Y, Hara H, Ushiogi Y, Hattori N. Low serum creatinine levels in severe hepatic disease. Arch Intern Med. 1988 Jun; 148(6):1313-1315.3377614
4. Durham SR, Bignell AH, Wise R. Interference of cefoxitin in the creatinine estimation and its clinical relevance. J Clin Pathol. 1979 Nov; 32(11):1148-1151.512029
5. Bowers LD, Wong ET. Kinetic serum creatinine assays. II: A critical evaluation and review. Clin Chem. 1980 Apr; 26(5):555-561.7020989
6. Soldin SJ, Henderson L, Hill JG. The effect of bilirubin and ketones on reaction rate methods for the measurement of creatinine. Clin Biochem. 1978 Jun; 11(3):82-86.688598
7. Roche Reagent Bulletin. TP-00523 Creatinine Jaffe Assays-Updated Endogenous Interference Claims. Dec 26, 2018.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 001370 | Creatinine | 2160-0 | 001370 | Creatinine | mg/dL | 2160-0 |
| 001370 | Creatinine | 2160-0 | 100779 | eGFR | mL/min/1.73 | 98979-8 |
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