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Chloride

CPT 82435

Test Details

Methodology

Ion-selective electrode (ISE)

Result Turnaround Time

Within 1 day

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Use

Evaluate electrolytes, acid-base balance, water balance. Chloride generally increases and decreases with plasma or serum sodium.

Chloride is increased in dehydration, with ammonium chloride administration, with renal tubular acidosis (hyperchloremic metabolic acidosis) and with excessive infusion of normal saline. Differential diagnosis of acidemias and alkalemias. Chloride is higher in hyperparathyroidism than in some of the other causes of hypercalcemia, but a great deal of overlap exists.

Chloride is decreased with overhydration, congestive failure, syndrome of inappropriate secretion of ADH, vomiting, gastric suction, chronic respiratory acidosis, Addison disease, salt-losing nephritis, burns, metabolic alkalosis, and in some instances of diuretic therapy.

Footnotes

1. Batlle DC, Hizon M, Cohen E, Gutterman C, Gupta R. The use of the urinary anion gap in the diagnosis of hyperchloremic metabolic acidosis. N Engl J Med. 1988 Mar 10; 318(10):594-599. 3344005

Custom Additional Information

Like other electrolytes, chloride cannot be interpreted without clinical knowledge of the patient. A diagnostic approach to the evaluation of hyperchloremic metabolic acidosis includes use of the urinary anion gap in conjunction with measurement of plasma potassium and urinary pH.1

Specimen Requirements

Specimen

Serum (preferred) or plasma

Volume

1 mL

Minimum Volume

0.7 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube, gel-barrier tube, or green-top (lithium heparin) tube. Do not use oxalate, EDTA, or citrate plasma.

Collection Instructions

Separate serum or plasma from cells within 45 minutes of collection.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Reference Range

96−106 mmol/L

*Reference interval has been verified for all age groups including pediatrics (birth to 18 years) and geriatrics.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Improper labeling

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
001206 Chloride 2075-0 001206 Chloride mmol/L 2075-0
Order Code001206
Order Code NameChloride
Order Loinc2075-0
Result Code001206
Result Code NameChloride
UofMmmol/L
Result LOINC2075-0