Test Details
Methodology
Inductively coupled plasma/mass spectrometry (ICP/MS)
Result Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Detect metal ion accumulation caused by metal-on-metal (MoM) implants.
Specimen Requirements
Specimen
Whole blood
Volume
4 mL
Minimum Volume
0.5 mL
Container
Royal blue-top (EDTA) metal-free tube
Reference Range
Reference interval is for patients with metal-on-metal (MoM) orthopedic implants. An algorithm intended as an aid for orthopedic surgeons in the assessment and management of patients with metal-on-metal bearings was published in 2014.1
The systematic risk stratification includes recommendations for multiple modes of failure and stratifies patient risk groups based on a thorough clinical history, a detailed physical examination, radiographic tests, and laboratory tests, including measurement of metal ions (chromium and cobalt).
The following stratification applies to chromium or cobalt as individual analytes, not to the combined total.
• Low risk group: <3.0 ng/mL
• Moderate risk group: 3.0−10.0 ng/mL
• High risk group: >10.0 ng/mL
Metal ion tests are an important adjunct to systemic clinical assessment; however, metal ion levels alone should not be relied on as the sole parameter to determine clinical recommendations for revision surgery.
Storage Instructions
Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 738770 | Chromium and Cobalt, WB (MoM) | 738771 | Chromium | ng/mL | 5619-2 | |
| 738770 | Chromium and Cobalt, WB (MoM) | 738772 | Cobalt | ng/mL | 5625-9 | |
| Order Code | 738770 | |||||
| Order Code Name | Chromium and Cobalt, WB (MoM) | |||||
| Order Loinc | ||||||
| Result Code | 738771 | |||||
| Result Code Name | Chromium | |||||
| UofM | ng/mL | |||||
| Result LOINC | 5619-2 | |||||
| Order Code | 738770 | |||||
| Order Code Name | Chromium and Cobalt, WB (MoM) | |||||
| Order Loinc | ||||||
| Result Code | 738772 | |||||
| Result Code Name | Cobalt | |||||
| UofM | ng/mL | |||||
| Result LOINC | 5625-9 |