Test Details
Methodology
Viscometry
Result Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Evaluate hyperviscosity syndrome associated with monoclonal gammopathy states (myeloma, macroglobulinemia of Waldenström, and other dysproteinemias), including occasional cases of rheumatoid arthritis, SLE, systemic lupus erythematosus, hyperfibrinogenemia
Limitations
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Footnotes
Custom Additional Information
Hyperviscosity most frequent (33% of cases)1 with IgM monoclonal gammopathy (Waldenström macroglobulinemia); next with IgA myeloma. When IgG myeloma leads to hyperviscosity, IgG levels are usually very significantly elevated. A relative viscosity of 6−7 usually results in symptoms of the hyperviscosity syndrome, they have however been described with lower levels of relative viscosity (ie, 4).2 Neonatal hyperviscosity, usually but not always associated with polycythemia, may be accompanied by a fairly typical clinical picture. Plethora, hypoglycemia, lethargy, and jitteriness/seizures (CNS symptoms) occur. There may be symptoms and findings suggesting congenital heart disease (CHD) (ie, respiratory distress, cardiac enlargement, and cyanosis). False diagnoses of CHD have been made in such cases. About 50% of such infants have modest hyperbilirubinemia (bilirubin >12 mg/dL).
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
• 0 to 5 years: Not established
• 6 to 50 years: 1.4−2.0 relative to saline
• >50 years: 1.4−2.1 relative to saline
Values >2.7 may indicate paraproteinemia is present.
Storage Instructions
Refrigerate.
Causes for Rejection
Hemolysis; fibrin clots; quantity not sufficient for analysis
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 004861 | Viscosity, Serum | 3128-6 | 004863 | Viscosity, Serum | rel.saline | 3128-6 |
| Order Code | 004861 | |||||
| Order Code Name | Viscosity, Serum | |||||
| Order Loinc | 3128-6 | |||||
| Result Code | 004863 | |||||
| Result Code Name | Viscosity, Serum | |||||
| UofM | rel.saline | |||||
| Result LOINC | 3128-6 |