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For hours, walk-ins and appointments.Test Includes
Creatinine, urine; thallium, urine; thallium:creatinine ratio
Special Instructions
Do not use preservative. Preservatives used for routine analysis may contain mercuric oxide (ie, Stabilur), which interferes with all metal testing. If both a routine urinalysis and metal testing are ordered, please submit a separate urine specimen (containing no additive) for the metal testing.
Expected Turnaround Time
4 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Urine (random or 24-hour)
Volume
5 mL
Minimum Volume
1.5 mL
Container
Plastic urine container, no preservative
Collection
Optional protocol: Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Avoid contact with metal during collection. Screw the lid on securely.
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Test Details
Use
Monitor industrial exposure to thallium
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Inductively-coupled plasma/mass spectrometry (ICP/MS)
Reference Interval
• Environmental exposure: <0.0−1.5 μg/L
• Thallium:creatinine ratio: 0.0−0.9 μg/g creatinine1
Additional Information
Thallium exposure, associated with industrial inhalation and/or dermal absorption of metallic thallium or thallium salts, may cause albuminuria, sensory changes, polyneuritis, speech disturbances, weakness, and visual impairment. Ingestion of soluble thallium salts is characterized by colic, nausea, vomiting, tremors, and paralysis.2 Thallium compounds are employed in semiconductor research, optical systems, and photoelectric cells. Thallium salts are also used as insecticides and rodenticides. Poisoning from occupational exposure to thallium can occur in the manufacture of optical instruments, rodenticides, dyes, and certain alloys. Environmental exposure may follow emissions from smelters, cement plants, and coal-fired plants.
Footnotes
1. Lauwerys RR, Hoet P. Industrial Chemical Exposure: Guidelines for Biological Monitoring. 2nd ed. Boca Raton, Fla: Lewis Publishers;1993:293.
2. Baselt RC, Cravey RH. Disposition of Toxic Drugs and Chemicals in Man. 4th ed. Chemical Toxicology Institute;1995.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 706580 | Thallium, Urine | 21558-2 | 706581 | Thallium, Urine | ug/L | 21558-2 |
| 706580 | Thallium, Urine | 21558-2 | 723280 | Creatinine(Crt),U | g/L | 2161-8 |
| 706580 | Thallium, Urine | 21558-2 | 706584 | Thallium/Crt Ratio | ug/g crt | 13469-2 |
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