Systemic Lupus Erythematosus (SLE) Profile C

TEST: 252908
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CPT: 86225; 86235(x4)
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Synonyms

  • ENA + dsDNA + Sjögren
  • SLE
  • SLE Profile C

Test Includes

Anti-dsDNA (double-stranded) antibody, quantitative; Sjögren's anti-SS-A; Sjögren's anti-SS-B; Smith antibody

Expected Turnaround Time

Within 1 day

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination; icterus

Test Details

Use

Sensitive assay for screening for ANAs in patients suspected of having SLE

Limitations

Low antibody levels may be found in diseases other than connective tissue disease.

Methodology

Multiplex bead flow cytometry

References

Kopnitsky M, Meenan J. AtheNA Multilyte ANA test system: The next generation of antinuclear testing. Clin Lab Products. 2002; 31:38-49.
Tan EM, Chan EK, Sullivan KF, et al. Antinuclear antibodies (ANAs): Diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity. Clin Immunol Immunopathol. 1988; 47(2):121-141. 3280190
von Mühlen CA, Nakamura RM. Clinical and laboratory evaluation of systemic rheumatic diseases. In: Henry JB, ed. Clinical Diagnosis and Management by Laboratory Methods. 20th ed. Philadelphia, Pa: WB Saunders Co; 2001: 974-989.
von Mühlen CA, Tan EM. Autoantibodies in the diagnosis of systemic rheumatic diseases. Semin Arthritis Rheum. 1995 Apr; 24(5):323-358. 7604300

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
252908 SLE Profile C 016354 RNP Antibodies AI 29374-6
252908 SLE Profile C 016362 Smith Antibodies AI 11090-8
252908 SLE Profile C 012684 Sjogren's Anti-SS-A AI 17792-3
252908 SLE Profile C 012692 Sjogren's Anti-SS-B AI 17791-5
252908 SLE Profile C 096343 Anti-DNA (DS) Ab Qn IU/mL 5130-0

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