Find Locations
For hours, walk-ins and appointments.Synonyms
- Rapamune®
Expected Turnaround Time
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Whole blood
Volume
3 mL
Minimum Volume
1.1 mL
Container
Lavender-top (EDTA) tube
Collection
Trough: 30 minutes to one hour before the next oral dose
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Patient Preparation
Trough levels are most reproducible.
Causes for Rejection
Clotted specimen
Test Details
Use
Monitor immunosuppressive therapy following organ transplant
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Reference Interval
3.0−20.0 ng/mL
Additional Information
Sirolimus may be administered in conjunction with cyclosporine (CsA) and corticosteroids to reduce or prevent host graft rejection. Using this therapy, peak concentrations are achieved in one to two hours. The mean terminal elimination half-life is 62 hours.1 Drug-drug interactions, including CsA, may alter the pharmacokinetics of sirolimus, making therapeutic drug monitoring appropriate.
Footnotes
1. MacDonald A, Scarola J, Burke JT, et al. Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus. Clin Ther. 2000; 22(Suppl B):B101-121 (review). 10823378
References
Taylor PJ, Johnson AG. Quantitative analysis of sirolimus (Rapamycin®) in blood by high-performance liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 1998; 718(2):251-257. 9840435
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 716712 | Sirolimus (Rapamune), Blood | 29247-4 | 716724 | Sirolimus, Blood | ng/mL | 29247-4 |
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