Sequential 2

TEST: 017750
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CPT: [MAAA: 81511] or 82105; 82677; 84702; 86336
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Synonyms

  • AFP, Maternal
  • Down Syndrome

Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. Patient must have submitted a previous specimen in the first trimester for the Sequential 1 test. Gestational age will be based on crown rump length provided with the first trimester specimen. Patient information may be provided to the laboratory using the Maternal Prenatal Screening test request form 0900. Testing is provided from 15.0 to 21.9 weeks of gestation.

Expected Turnaround Time

2 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

3 mL

Container

Gel-barrier tube

Collection

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.

Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

Test Details

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Limitations

Sequential screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the second trimester portion of the test. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Chemiluminescent immunoassay

References

Wald NJ, Rudnicka AR, Bestwick JP. Sequential and contingent prenatal screening for Down syndrome. Prenat Diagn. 2006 Sep; 26(9):769-777.16821246

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
017750 Sequential 2 017869 Results N/A
017750 Sequential 2 017751 Test Results: 49586-1
017750 Sequential 2 017753 FIRST TRIMESTER SAMPLE N/A
017750 Sequential 2 017754 Crown Rump Length mm 11957-8
017750 Sequential 2 018055 Crown Rump Length Twin B mm 11957-8
017750 Sequential 2 017755 CRL Scan 34970-4
017750 Sequential 2 018056 CRL Scan Twin B 34970-4
017750 Sequential 2 018022 Sonographer ID# 49089-6
017750 Sequential 2 017757 Collected On 33882-2
017750 Sequential 2 017758 Gest. Age on Collection Date weeks 18185-9
017750 Sequential 2 017759 Weight lbs 29463-7
017750 Sequential 2 017760 SECOND TRIMESTER SAMPLE N/A
017750 Sequential 2 017761 Collected On 33882-2
017750 Sequential 2 017762 Gestational Age weeks 18185-9
017750 Sequential 2 017763 Weight lbs 29463-7
017750 Sequential 2 017765 Maternal Age at EDD yr 43993-5
017750 Sequential 2 017766 Race 21484-1
017750 Sequential 2 017894 Insulin Dep Diabetes 44877-9
017750 Sequential 2 017767 Number of Fetuses 11878-6
017750 Sequential 2 017768 Nuchal Translucency (NT) mm 12146-7
017750 Sequential 2 017769 Nuchal Translucency MoM 49035-9
017750 Sequential 2 018054 NT Twin B mm 12146-7
017750 Sequential 2 018071 NT MoM Twin B 49035-9
017750 Sequential 2 018204 Additional US N/A
017750 Sequential 2 018224 PAPP-A Value ng/mL 48407-1
017750 Sequential 2 017782 PAPP-A MoM 76348-2
017750 Sequential 2 017262 AFP Value ng/mL 1834-1
017750 Sequential 2 017784 AFP MoM 23811-3
017750 Sequential 2 017266 hCG Value IU/mL 19080-1
017750 Sequential 2 017786 hCG MoM 32166-1
017750 Sequential 2 017268 uE3 Value ng/mL 2250-9
017750 Sequential 2 017788 uE3 MoM 21264-7
017750 Sequential 2 017280 DIA Value pg/mL 23883-2
017750 Sequential 2 017790 DIA MoM 36904-1
017750 Sequential 2 018105 Open Spina Bifida 48803-1
017750 Sequential 2 018106 Down Syndrome 43995-0
017750 Sequential 2 018107 Down Syndrome 49090-4
017750 Sequential 2 018108 Trisomy 18 43994-3
017750 Sequential 2 018109 Trisomy 18 47223-3
017750 Sequential 2 017796 OSB Interpretation 49586-1
017750 Sequential 2 017752 Down Syndrome Interpretation 49586-1
017750 Sequential 2 017797 Trisomy 18 Interpretation 49586-1
017750 Sequential 2 017798 Comments: 77202-0
017750 Sequential 2 017862 Note: N/A
017750 Sequential 2 511933 PDF 11502-2

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