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RET Oncology FISH

CPT

Contact CPT coding department at 800-222-7566, ext 6-8400.

Synonyms
  • Adenocarcinoma
  • Non−Small-cell Lung Cancer
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  • Updated on 03/31/2025

Test Details

Methodology

Fluorescence in situ hybridization (FISH)

Result Turnaround Time

5 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Use

This test is used for confirmation/identification of cancer-related alterations in non−small-cell lung cancer.

Confirmation/identification of cancer-related alterations in non−small-cell lung cancer

This test is used for confirmation/identification of cancer-related alterations in non−small-cell lung cancer.

Limitations

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

References

Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012 Feb 12; 18(3):378-381.

Specimen Requirements

Specimen

FNA; formalin-fixed paraffin-embedded blocks are acceptable

FNA; formalin-fixed paraffin-embedded blocks are acceptable.

FNA; formalin-fixed paraffin-embedded blocks are acceptable

Volume

Five slides (4- to 5-micron thick sections)

Minimum Volume

Two slides (4- to 5-micron thick sections) on positively charged slides or one paraffin block (Note: This volume does not allow for repeat testing.)

Two slides (4- to 5-micron thick sections)

Two slides (4- to 5-micron thick sections) on positively charged slides or one paraffin block (Note: This volume does not allow for repeat testing.)

Container

Paraffin block

Collection Instructions

Utilize sterile technique and Labcorp transport kits when possible.

Utilize sterile technique and Labcorp transport kits when possible.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; absence of tumor or quantity not sufficient for analysis

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510315 RET Oncology FISH 510893 Specimen Type 31208-2
510315 RET Oncology FISH 510894 Cells Counted 62361-1
510315 RET Oncology FISH 510895 Cells Analyzed 62360-3
510315 RET Oncology FISH 510896 FISH Result 48674-6
510315 RET Oncology FISH 510316 Interpretation 62365-2
510315 RET Oncology FISH 510317 Director Review 48672-0
Order Code510315
Order Code NameRET Oncology FISH
Order Loinc
Result Code510893
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code510315
Order Code NameRET Oncology FISH
Order Loinc
Result Code510894
Result Code NameCells Counted
UofM
Result LOINC62361-1
Order Code510315
Order Code NameRET Oncology FISH
Order Loinc
Result Code510895
Result Code NameCells Analyzed
UofM
Result LOINC62360-3
Order Code510315
Order Code NameRET Oncology FISH
Order Loinc
Result Code510896
Result Code NameFISH Result
UofM
Result LOINC48674-6
Order Code510315
Order Code NameRET Oncology FISH
Order Loinc
Result Code510316
Result Code NameInterpretation
UofM
Result LOINC62365-2
Order Code510315
Order Code NameRET Oncology FISH
Order Loinc
Result Code510317
Result Code NameDirector Review
UofM
Result LOINC48672-0