Skip to main content

Proliferation Marker Ki67, Paraffin Block

Test Number 481051
Test number copied
CPT 88360
Synonyms
  • Ki67

Test Details

Methodology

Immunohistochemistry (IHC)

Result Turnaround Time

5 - 9 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Use

Cancer prognosis: Evaluation of cellular proliferation in tumors which, when combined with other prognostic markers can provide information for patient management and therapy.

Special Instructions

Please direct any questions regarding this test to oncology customer service at 800-345-4363.

Limitations

Use of fixatives other than 10% formalin may not yield equivalent or satisfactory results.

This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

Custom Additional Information

Studies have shown a strong correlation between proliferation rate and clinical outcome in a variety of tumor types, and measurement of cell proliferative activity is one of several important prognostic markers.1 A high level of staining for this nuclear proliferation marker in breast carcinomas is associated with an increased risk of early recurrence.2-4

Specimen Requirements

Specimen

Formalin-fixed, paraffin-embedded (FFPE) tumor

Volume

One paraffin block

Container

Paraffin block transport pouch

Collection Instructions

Specimen should be fixed in 10% neutral-buffered formalin. Optimum fixation time is 12 to 24 hours, not to exceed 48 hours.

Storage Instructions

Maintain specimen at room temperature.

Footnotes

1. Hall PA, Levison DA. Assessment of cell proliferation in histologic material. J Clin Pathol. 1990 Mar; 43(3):184-192 (review). 2185282
2. Bouzubar N, Walker KJ, Griffiths K, et al. Ki67 immunostaining in primary breast cancer: Pathological and clinical associations. Br J Cancer. 1989 Jun; 59(6):943-947. 2472168
3. Veronese SM, Gambacorta M. Detection of Ki67 proliferation rate in breast cancer. Correlation with clinical and pathologic features. Am J Clin Pathol. 1991 Jan; 95(1):30-34. 1987749
4. Fitzgibbons PL, Page DL, Weaver D, et al. Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med. 2000 Jul; 124(7):966-978. 10888772

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
481051 Prolif Marker MIB-1, Paraffin 481060 % Positive Tumor Nuclei % 29593-1
481051 Prolif Marker MIB-1, Paraffin 481130 Comment: 77202-0
Order Code481051
Order Code NameProlif Marker MIB-1, Paraffin
Order Loinc
Result Code481060
Result Code Name% Positive Tumor Nuclei
UofM%
Result LOINC29593-1
Order Code481051
Order Code NameProlif Marker MIB-1, Paraffin
Order Loinc
Result Code481130
Result Code NameComment:
UofM
Result LOINC77202-0