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p53 Oncology FISH

CPT

Contact CPT coding department at 800-222-7566, ext 6-8400.

Synonyms
  • FISH
  • Leukemia FISH
  • Lymphoma FISH
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  • Updated on 03/31/2025

Test Details

Methodology

Fluorescence in situ hybridization (FISH)

Result Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Test Includes

Include pertinent clinical diagnosis and previous cytogenetic studies on the test request form.

Include pertinent clinical diagnosis and previous cytogenetic studies on the test request form.

Use

This test is used for confirmation/identification of leukemia/lymphoma-related alterations and leukemia/lymphoma monitoring of residual disease, transplants and indolent clones (see list or call lab for probe availability).

Confirmation/identification of leukemia/lymphoma-related alterations; leukemia/lymphoma monitoring of residual disease, transplants, and indolent clones (see list or call lab for probe availability)

This test is used for confirmation/identification of leukemia/lymphoma-related alterations and leukemia/lymphoma monitoring of residual disease, transplants and indolent clones (see list or call lab for probe availability).

Limitations

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Whole blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei or bone marrow touch preparation slides are acceptable for testing.

Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA are also acceptable.

Whole blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei or bone marrow touch preparation slides are acceptable for testing.

Volume

5 mL whole blood (pediatric), 3 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 2 slides with metaphase and/or interphase nuclei or 2 touch preparation slides

Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

5 mL whole blood (pediatric), 3 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 2 slides with metaphase and/or interphase nuclei or 2 touch preparation slides

Minimum Volume

1 mL whole blood (pediatric), 1 mL bone marrow, fixed-cell pellet from cytogenetic analysis, 1 slide with metaphase and/or interphase nuclei or 1 touch preparation slide (Note: Minimum volumes may not allow for repeat testing.)

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow

1 mL whole blood (pediatric), 1 mL bone marrow, fixed-cell pellet from cytogenetic analysis, 1 slide with metaphase and/or interphase nuclei or 1 touch preparation slide (Note: Minimum volumes may not allow for repeat testing.)

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample.

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample.

Collection Instructions

Utilize sterile technique and Labcorp transport kits when possible.

Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.

Utilize sterile technique and Labcorp transport kits when possible.

Storage Instructions

Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.

Maintain specimen at room temperature.

Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.

Causes for Rejection

Broken Vacutainer®; broken or stained slides; decalcified bone core; frozen specimen; quantity not sufficient for analysis

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen

Broken Vacutainer®; broken or stained slides; decalcified bone core; frozen specimen; quantity not sufficient for analysis

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510940 P53 Oncology FISH 510250 Specimen Type 31208-2
510940 P53 Oncology FISH 510251 Cells Counted N/A
510940 P53 Oncology FISH 510254 Cells Analyzed N/A
510940 P53 Oncology FISH 510943 FISH Result 48674-6
510940 P53 Oncology FISH 510257 Interpretation 50398-7
510940 P53 Oncology FISH 510944 Director Review: 48672-0
Order Code510940
Order Code NameP53 Oncology FISH
Order Loinc
Result Code510250
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code510940
Order Code NameP53 Oncology FISH
Order Loinc
Result Code510251
Result Code NameCells Counted
UofM
Result LOINCN/A
Order Code510940
Order Code NameP53 Oncology FISH
Order Loinc
Result Code510254
Result Code NameCells Analyzed
UofM
Result LOINCN/A
Order Code510940
Order Code NameP53 Oncology FISH
Order Loinc
Result Code510943
Result Code NameFISH Result
UofM
Result LOINC48674-6
Order Code510940
Order Code NameP53 Oncology FISH
Order Loinc
Result Code510257
Result Code NameInterpretation
UofM
Result LOINC50398-7
Order Code510940
Order Code NameP53 Oncology FISH
Order Loinc
Result Code510944
Result Code NameDirector Review:
UofM
Result LOINC48672-0