Test Details
Methodology
HE4: enzyme-linked immunosorbent assay (ELISA); CA 125: electrochemiluminescence immunoassay (ECLIA)
Result Turnaround Time
1 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Human Epididymis Protein 4 [081700]; Cancer Antigen 125 [002303]. See individual test descriptions for complete information.
Use
Use of HE4 in combination with CA 125 provides a more accurate predictor of malignancy than either marker alone.
Special Instructions
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.8 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection Instructions
If red-top tube is used, transfer separated serum to a plastic transport tube.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 5 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Storage Instructions
Refrigerate
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 081610 | Ovarian Cancer Monitor | 002321 | Cancer Antigen (CA) 125 | U/mL | 10334-1 | |
| 081610 | Ovarian Cancer Monitor | 081750 | HE4 | pmol/L | 55180-4 | |
| Order Code | 081610 | |||||
| Order Code Name | Ovarian Cancer Monitor | |||||
| Order Loinc | ||||||
| Result Code | 002321 | |||||
| Result Code Name | Cancer Antigen (CA) 125 | |||||
| UofM | U/mL | |||||
| Result LOINC | 10334-1 | |||||
| Order Code | 081610 | |||||
| Order Code Name | Ovarian Cancer Monitor | |||||
| Order Loinc | ||||||
| Result Code | 081750 | |||||
| Result Code Name | HE4 | |||||
| UofM | pmol/L | |||||
| Result LOINC | 55180-4 |