Nicotine and Metabolite, Quantitative, Plasma, Whole Blood, or Serum

TEST: 071255
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CPT: 80323
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Synonyms

  • Tobacco

Expected Turnaround Time

3 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Plasma, whole blood, or serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

Lavender-top (EDTA) tube, green-top (heparin) tube, or red-top tube

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Test Details

Use

Measurement of nicotine and its metabolites to monitor success of smoking cessation programs, detect passive exposure, and evaluate nontobacco nicotine exposure

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

References

Analytical Validation Report. Quantification of Nicotine and Metabolites by LC-MS/MS Analysis. Unpublished LabCorp Internal Document Number VR-NOQS-BN-2008-06.
James G, et al. A Highly Sensitive Method for the Quantitation of Nicotine, Cotinine, and Trans-3'-Hydroxycotinine in Human Plasma (EDTA). ASMS Poster 1014, 2007.
Moyer TP, Charlson JR, Enger RJ, et al. Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles. Clin Chem. 2002 Sep; 48(9):1460-1471. 12194923
Xu X, Iba MM, Weisel CP. Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry. Clin Chem. 2004 Dec; 50(12):2323-2330. 15472033

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
071255 Nicotine and Metabolite, Quant 90226-2 071259 Nicotine ng/mL 3853-9
071255 Nicotine and Metabolite, Quant 90226-2 071260 Cotinine ng/mL 10365-5

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