Myeloproliferative Neoplasms/Chronic Myelogenous Leukemia (MPN/CML), FISH

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Synonyms

  • Leukemia/Lymphoma-specific FISH
  • Myeloproliferative Neoplasms

Test Includes

Fluorescence in situ hybridization (FISH) for myeloproliferative neoplasms/chronic myelogenous leukemia (MPN/CML) targeting numerical changes of chromosomes 8, 9, 13q14, and rearrangement of BCR/ABL1.


Special Instructions

Include the pertinent clinical diagnosis, previous cytogenetic studies, and probe of interest with the test request form.


Expected Turnaround Time

3 - 5 days



Related Documents


Specimen Requirements


Specimen

Bone marrow, blood, cerebrospinal fluid (CSF), FNA, bone marrow touch prep slides


Volume

3 mL bone marrow (For additional cytogenetic studies an additional 1 mL of bone marrow is required.), fixed-cell pellet, three slides


Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, five slides, 2 mL blood, or 1 mL bone marrow (For additional cytogenetic studies, an additional 1 mL of bone marrow is required.)


Container

Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube


Storage Instructions

Maintain specimens at room temperature.


Causes for Rejection

Broken or dirty slides; excessive cellular debris; stains on slides


Test Details


Use

Confirmation/identification of chromosome abnormalities in interphase nuclei. Leukemia monitoring of residual disease.


Methodology

Fluorescence in situ hybridization (FISH)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511425 MPN/CML FISH 511087 Specimen Type 31208-2
511425 MPN/CML FISH 511088 Cells Counted 62361-1
511425 MPN/CML FISH 511091 Cells Analyzed 62360-3
511425 MPN/CML FISH 511092 FISH Result 62356-1
511425 MPN/CML FISH 511093 Interpretation 62365-2
511425 MPN/CML FISH 511094 Director Review: 48672-0
511425 MPN/CML FISH 512123 PDF 51967-8

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