Test Details
Methodology
Latex agglutination (LA)
Result Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Endpoint titer is performed at an additional charge when preliminary qualitative test is positive.
Use
Detect heterophil antibodies related to infectious mononucleosis
Limitations
Rare patients may have positive heterophil agglutinins after a negative initial test. Ten percent of cases of true EBV mononucleosis may have negative heterophil agglutinins. These may be diagnosed with EBV specific tests.
Custom Additional Information
A positive test in the presence of consistent clinical and/or hematologic findings confirms the diagnosis of infectious mononucleosis. Approximately 10% of mononucleosis syndromes are heterophil-negative. In some of these, antibody to specific Epstein-Barr viral antigen can be demonstrated. Others may be due to CMV, HSV, or toxoplasmosis. Although this classic test has excellent specificity, false-positive tests can occur and may lead to diagnostic confusion.
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
Negative
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 006536 | Mono Qual W/Rflx Qn | 5213-4 | 006536 | Mono Qual W/Rflx Qn | 5213-4 | |
| Order Code | 006536 | |||||
| Order Code Name | Mono Qual W/Rflx Qn | |||||
| Order Loinc | 5213-4 | |||||
| Result Code | 006536 | |||||
| Result Code Name | Mono Qual W/Rflx Qn | |||||
| UofM | ||||||
| Result LOINC | 5213-4 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 006569 | Mononucleosis Test, Quant | 016569 | Mono Titer | 6424-6 | |
| Reflex 1 | ||||||
| Order Code | 006569 | |||||
| Order Name | Mononucleosis Test, Quant | |||||
| Result Code | 016569 | |||||
| Result Name | Mono Titer | |||||
| UofM | ||||||
| Result LOINC | 6424-6 | |||||