Albumin/Creatinine Ratio, Random Urine

Albumin accounts for approximately 50% of the protein in plasma.² The kidney works to prevent the loss of albumin into the urine through active resorption, but a small amount of albumin can be measured in urine of individuals with normal renal function.

The prognostic value of consistently elevated albumin levels is particularly well established in diabetic patients.¹ Renal disease is a common microvascular complication of diabetes. Without specific interventions, 80% of type I diabetics with repeatedly elevated albumin levels will go on to end-stage renal disease. Twenty percent to 40% of type II diabetics with sustained albuminuria will progress to overt nephropathy.

The American Diabetes Association (ADA) recommends that routine urinalysis be performed annually on adults with diabetes.¹ If the urinalysis is negative for protein, albumin measurement is recommended. The ADA also recommends annual screening of children beginning at puberty or after five years of disease duration. The reference intervals stated above reflect the diagnostic criteria prescribed by the ADA.¹