Find Locations
For hours, walk-ins and appointments.Synonyms
- Metanephrines, Random Urine
- Pheochromocytoma Evaluation
Test Includes
Creatinine; normetanephrine; metanephrine; metanephrine:creatinine ratio
Expected Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Urine (first morning)
Volume
10 mL
Minimum Volume
2.5 mL (Note: This volume does not allow for repeat testing.)
Container
Random urine transport tube with no preservative or 6N HCl
Collection
Collect urine and transfer to a random urine transport tube.
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 14 days |
Patient Preparation
Medication and dietary monitoring. A number of drugs act through catecholamine mechanisms and must be discontinued 72 hours before and during collection. Bananas, pineapple, and plums are contraindicated.
Test Details
Use
Diagnose the presence of a pheochromocytoma, neuroblastoma, and ganglioneuroblastoma
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Metanephrines: liquid chromatography/tandem mass spectrometry (LC/MS-MS); creatinine: alkaline picric acid
Additional Information
Simultaneous measurement of urine creatinine permits expression of the metanephrine:creatinine ratio. Some clinicians use >2.2 μg metanephrines/mg creatinine to distinguish pheochromocytoma from normal with this ratio.1
Footnotes
1. Gitlow SE, Mendlowitz M, Bertani LM. The biochemical techniques for detecting and establishing the presence of a pheochromocytoma. A review of ten years' experience. Am J Cardiol. 1970 Sep; 26(3):270-279. 5505453
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 004044 | Metanephrines, Pheochromocyt | 68317-7 | 070016 | Creatinine, Random U | mg/dL | 2161-8 |
| 004044 | Metanephrines, Pheochromocyt | 68317-7 | 004240 | Normetanephrine, Ur | ug/L | 21422-1 |
| 004044 | Metanephrines, Pheochromocyt | 68317-7 | 004239 | Metanephrine, Ur | ug/L | 21019-5 |
| 004044 | Metanephrines, Pheochromocyt | 68317-7 | 070028 | Metaneph/Creat Ratio | ug/mg Creat | 13771-1 |
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