Test Details
Methodology
Metanephrines: liquid chromatography/tandem mass spectrometry (LC/MS-MS); creatinine: alkaline picric acid
Result Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Creatinine; normetanephrine; metanephrine; metanephrine:creatinine ratio
Use
Diagnose the presence of a pheochromocytoma, neuroblastoma, and ganglioneuroblastoma
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Custom Additional Information
Simultaneous measurement of urine creatinine permits expression of the metanephrine:creatinine ratio. Some clinicians use >2.2 μg metanephrines/mg creatinine to distinguish pheochromocytoma from normal with this ratio.1
Specimen Requirements
Specimen
Urine (first morning)
Volume
10 mL
Minimum Volume
2.5 mL (Note: This volume does not allow for repeat testing.)
Container
Random urine transport tube with no preservative or 6N HCl
Collection Instructions
Collect urine and transfer to a random urine transport tube.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 14 days |
Storage Instructions
Room temperature
Patient Preparation
Medication and dietary monitoring. A number of drugs act through catecholamine mechanisms and must be discontinued 72 hours before and during collection. Bananas, pineapple, and plums are contraindicated.
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 004044 | Metanephrines, Pheochromocyt | 68317-7 | 070016 | Creatinine, Random U | mg/dL | 2161-8 |
| 004044 | Metanephrines, Pheochromocyt | 68317-7 | 004240 | Normetanephrine, Ur | ug/L | 21422-1 |
| 004044 | Metanephrines, Pheochromocyt | 68317-7 | 004239 | Metanephrine, Ur | ug/L | 21019-5 |
| 004044 | Metanephrines, Pheochromocyt | 68317-7 | 070028 | Metaneph/Creat Ratio | ug/mg Creat | 13771-1 |
| Order Code | 004044 | |||||
| Order Code Name | Metanephrines, Pheochromocyt | |||||
| Order Loinc | 68317-7 | |||||
| Result Code | 070016 | |||||
| Result Code Name | Creatinine, Random U | |||||
| UofM | mg/dL | |||||
| Result LOINC | 2161-8 | |||||
| Order Code | 004044 | |||||
| Order Code Name | Metanephrines, Pheochromocyt | |||||
| Order Loinc | 68317-7 | |||||
| Result Code | 004240 | |||||
| Result Code Name | Normetanephrine, Ur | |||||
| UofM | ug/L | |||||
| Result LOINC | 21422-1 | |||||
| Order Code | 004044 | |||||
| Order Code Name | Metanephrines, Pheochromocyt | |||||
| Order Loinc | 68317-7 | |||||
| Result Code | 004239 | |||||
| Result Code Name | Metanephrine, Ur | |||||
| UofM | ug/L | |||||
| Result LOINC | 21019-5 | |||||
| Order Code | 004044 | |||||
| Order Code Name | Metanephrines, Pheochromocyt | |||||
| Order Loinc | 68317-7 | |||||
| Result Code | 070028 | |||||
| Result Code Name | Metaneph/Creat Ratio | |||||
| UofM | ug/mg Creat | |||||
| Result LOINC | 13771-1 |