Test Details
Methodology
Inductively-coupled plasma/mass spectrometry (ICP/MS)
Result Turnaround Time
2 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Confirm manganese exposure, toxicity, or poisoning by documenting excessive urine excretion of the metal. Also used to individualize manganese dosing in long-term parenteral nutrition, especially in liver disease, when biliary excretion is low, or when there is excessive gastrointestinal losses, such as in short bowel syndrome. Has been used to follow the success of chelation therapy with para-aminosalicylate sodium in manganism.
Special Instructions
Do not use preservative. Preservatives used for routine analysis may contain mercuric oxide (ie, Stabilur), which interferes with all metal testing. If both urinalysis and metal testing are ordered, please submit a separate urine specimen (containing no additive) for the metal testing.
Limitations
Levels in urine are so low that considerable error may be introduced by contamination. Manganese toxicity may leave residual neurologic damage after serum and urine levels have returned to normal, masking the original cause.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Custom Additional Information
Manganese poisoning through acute exposure may produce symptoms of fever, muscle pains, chills, and dryness of the mouth and throat. Chronic exposures to manganese may be evidenced by effects on the CNS (eg, headache, restlessness, irritability, personality change, hallucinations, and hearing impairment).2 Levels may be reduced mildly in epilepsy and raised in hepatitis or jaundice.3 Urine manganese is used in conjunction with plasma manganese to evaluate possible toxicity or deficiency of manganese, an essential mineral. High concentrations can cause nausea, headache, and psychiatric disturbances with neurological damage similar to Parkinson disease. Normalization of plasma may not reverse the neurological damage.
Specimen Requirements
Specimen
Urine (random)
Volume
20 mL
Minimum Volume
1.7 mL
Container
Plastic urine container, no preservative
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
Environmental exposure: 0.0−2.9 μg/L1
Storage Instructions
Maintain specimen at room temperature.
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 071597 | Manganese, Urine | 58736-0 | 071598 | Manganese, Urine | ug/L | 5684-6 |
| 071597 | Manganese, Urine | 58736-0 | 723280 | Creatinine(Crt),U | g/L | 2161-8 |
| 071597 | Manganese, Urine | 58736-0 | 071599 | Manganese/Crt Ratio | ug/g creat | 27367-2 |
| Order Code | 071597 | |||||
| Order Code Name | Manganese, Urine | |||||
| Order Loinc | 58736-0 | |||||
| Result Code | 071598 | |||||
| Result Code Name | Manganese, Urine | |||||
| UofM | ug/L | |||||
| Result LOINC | 5684-6 | |||||
| Order Code | 071597 | |||||
| Order Code Name | Manganese, Urine | |||||
| Order Loinc | 58736-0 | |||||
| Result Code | 723280 | |||||
| Result Code Name | Creatinine(Crt),U | |||||
| UofM | g/L | |||||
| Result LOINC | 2161-8 | |||||
| Order Code | 071597 | |||||
| Order Code Name | Manganese, Urine | |||||
| Order Loinc | 58736-0 | |||||
| Result Code | 071599 | |||||
| Result Code Name | Manganese/Crt Ratio | |||||
| UofM | ug/g creat | |||||
| Result LOINC | 27367-2 |