Test Details
Methodology
Enzyme immunoassay (EIA)
Result Turnaround Time
2 - 6 days
Use
Aid in the diagnosis of past infection/exposure to roseola infantum; may be useful in diagnosis of chronic fatigue syndrome
Specimen Requirements
Limitations
This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.
References
Custom Additional Information
Human herpesvirus 6 (HHV-6) has recently been identified as the agent associated with both pediatric and adult infections. Most children have been infected by age three. The acute infection in children is characterized clinically by an acute febrile illness, irritability, inflammation of tympanic membranes, and (uncommonly) a rash characteristic of roseola.
In adults, HHV-6 has been associated with chronic fatigue and spontaneously resolving fever resembling a mononucleosis-like illness. During the acute episode an elevated IgM HHV-6 is useful. An increase in IgG HHV-6 between acute and convalescent serum sample is consistent with a recent HHV-6 infection.
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
Collection Instructions
Specimen should be free of bacterial contamination, hemolysis, and lipemia.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x4 |
Reference Range
• Negative: <0.90 index
• Equivocal: 0.90−1.10 index
• Positive: >1.10 index
Fourfold rises in titer are suggestive of either recent, primary, or reactivated infection. The presence of elevated titers to HHV-6 in the absence of responses to HAV, HBV, CMV, and EMV suggests that titer results are associated with high specificity.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 161075 | HHV 6 IgG Antibodies | 41148-8 | 161076 | HHV 6 IgG Antibodies | index | 41148-8 |
| Order Code | 161075 | |||||
| Order Code Name | HHV 6 IgG Antibodies | |||||
| Order Loinc | 41148-8 | |||||
| Result Code | 161076 | |||||
| Result Code Name | HHV 6 IgG Antibodies | |||||
| UofM | index | |||||
| Result LOINC | 41148-8 |