Hemoglobin (Hb) Solubility With Reflex to Hemoglobinopathy Fractionation Cascade, Blood

Test Number 005330

Test number copied

CPT 85660. If reflex testing is performed, concomitant CPT codes/charges will apply.

Synonyms

Hb Solubility
Sickle Cell Preparation
Sickle Cell Solubility Test
Sickle Cell Test
Sickle Prep
Sickledex™

Test Details

Methodology

Sodium hydrosulfite reduction

Result Turnaround Time

2 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Hemoglobin (Hb) Solubility

Test Includes

Hemoglobin (Hb) solubility and automatic reflex to hemoglobin (Hb) fractionation blood (at additional charge), if positive.

Use

Qualitative determination of presence of hemoglobin S; detect sickling hemoglobins; evaluate hemolytic anemia, undiagnosed hereditary anemia with morphologic (sickle-like) abnormalities on peripheral blood smear

Limitations

See Hemoglobin (Hb) Solubility [005223].

Custom Additional Information

See Hemoglobin (Hb) Solubility [005223].

Specimen Requirements

Specimen

Whole blood

Volume

1 mL

Minimum Volume

0.6 mL (Note: This volume does not allow for repeat testing.)

Container

Lavender-top (EDTA) tube; capillary puncture: three microhematocrit tubes

Note: Because this profile reflexes to Hemoglobinopathy Fractionation Cascade [121690] when positive, only a Lavender-top (EDTA) tube is allowed.

Collection Instructions

To avoid delays in turnaround time, please submit a separate lavender-top tube for each test requiring a lavender-top.

Stability Requirements

Temperature	Period
Room temperature	14 days
Refrigerated	14 days
Frozen	14 days
Freeze/thaw cycles	Stable x3

Reference Range

Negative

Storage Instructions

Room temperature

Patient Preparation

No preliminary fluid or food restriction is required.

Causes for Rejection

Specimen other than whole blood received; clotted specimen

References

Chehab FF, Kan YW. Detection of sickle cell anaemia mutation by colour DNA amplification. Lancet. 1990 Jan 6; 335(8680):15-17. 1967329

Miale JB. Laboratory Medicine: Hematology. 6th ed. St Louis, Mo: Mosby-Year Book Inc;1982:624-625.

LOINC® Map

Order Code	Order Code Name	Order Loinc	Result Code	Result Code Name	Result LOINC
005330	HB Solu + Rflx Frac	6864-3	005224	Hemoglobin (Hgb) Solubility	6864-3
Order Code	005330
Order Code Name	HB Solu + Rflx Frac
Order Loinc	6864-3
Result Code	005224
Result Code Name	Hemoglobin (Hgb) Solubility
UofM
Result LOINC	6864-3

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121692	Hgb F	%	32682-7
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121692
Result Name	Hgb F
UofM	%
Result LOINC	32682-7

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121693	Hgb A	%	20572-4
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121693
Result Name	Hgb A
UofM	%
Result LOINC	20572-4

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121694	Hgb A2	%	4552-6
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121694
Result Name	Hgb A2
UofM	%
Result LOINC	4552-6

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121695	Hgb S	%	32683-5
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121695
Result Name	Hgb S
UofM	%
Result LOINC	32683-5

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

Reflex Table for Hemoglobin (Hgb) Solubility
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	121690	Hgb Fractionation Cascade	121696	Interpretation:	12710-0
Reflex 1
Order Code	121690
Order Name	Hgb Fractionation Cascade
Result Code	121696
Result Name	Interpretation:
UofM
Result LOINC	12710-0

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