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Heart Disease and Stroke Risk Profile

CPT 83695; 85246; 85384; 86141

Test Details

Methodology

See individual tests.

Result Turnaround Time

2 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Procedures for Hemostasis and Thrombosis: A Clinical Test Compendium

Test Includes

C-reactive protein, cardiac; fibrinogen activity; lipoprotein (a); von Willebrand factor antigen

Special Instructions

State patient's sex on the request form. If the patient's hematocrit exceeds 55%, the volume of citrate in the collection tube must be adjusted. Refer to Coagulation Collection Procedures for directions.

Footnotes

1. Adcock DM, Kressin DC, Marlar RA. Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing. Am J Clin Pathol. 1997 Jan; 107(1):105-110. 8980376
2. Reneke J, Etzell J, Leslie S, Ng VL, Gottfried EL. Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant. Am J Clin Pathol. 1998 Jun; 109(6):754-757. 9620035
3. National Committee for Clinical Laboratory Standardization. Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and General Performance of Coagulation Assays; Approved Guideline. 5th ed. Villanova, Pa: NCCLS; 2008. Document H21-A5:28(5).
4. Gottfried EL, Adachi MM. Prothrombin time and activated partial thromboplastin time can be performed on the first tube. Am J Clin Pathol. 1997 Jun; 107(6):681-683. 9169665
5. McGlasson DL, More L, Best HA, Norris WL, Doe RH, Ray H. Drawing specimens for coagulation testing: Is a second tube necessary? Clin Lab Sci. 1999 May-Jun; 12(3):137-139. 10539100

Specimen Requirements

Specimen

Serum and plasma, frozen

Volume

1 mL serum and 1 mL frozen plasma

Container

Red-top tube or gel-barrier tube and blue-top (sodium citrate) tube or lavender-top (EDTA) tube

Collection Instructions

Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples, except when using a winged blood collection device (ie, "butterfly"), in which case a discard tube should be used.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.

Storage Instructions

Refrigerate serum. Freeze plasma.

Patient Preparation

Do not draw from an arm with a heparin lock or heparinized catheter.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
500140 Heart Disease/Stroke Risk 120190 Lipoprotein (a) nmol/L 43583-4
500140 Heart Disease/Stroke Risk 120768 C-Reactive Protein, Cardiac mg/L 30522-7
500140 Heart Disease/Stroke Risk 001702 Fibrinogen Activity mg/dL 3255-7
500140 Heart Disease/Stroke Risk 086280 von Willebrand Factor (vWF) Ag % 27816-8
Order Code500140
Order Code NameHeart Disease/Stroke Risk
Order Loinc
Result Code120190
Result Code NameLipoprotein (a)
UofMnmol/L
Result LOINC43583-4
Order Code500140
Order Code NameHeart Disease/Stroke Risk
Order Loinc
Result Code120768
Result Code NameC-Reactive Protein, Cardiac
UofMmg/L
Result LOINC30522-7
Order Code500140
Order Code NameHeart Disease/Stroke Risk
Order Loinc
Result Code001702
Result Code NameFibrinogen Activity
UofMmg/dL
Result LOINC3255-7
Order Code500140
Order Code NameHeart Disease/Stroke Risk
Order Loinc
Result Code086280
Result Code Namevon Willebrand Factor (vWF) Ag
UofM%
Result LOINC27816-8