Test Details
Methodology
Fluorescence in situ hybridization (FISH)
Result Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This test is used for confirmation/identification of leukemia/lymphoma-related alterations and leukemia/lymphoma monitoring of residual disease, transplants and indolent clones (see list or call lab for probe availability).
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This test is used for confirmation/identification of leukemia/lymphoma-related alterations and leukemia/lymphoma monitoring of residual disease, transplants and indolent clones (see list or call lab for probe availability). |
Special Instructions
Call for additional probes not listed above. Pertinent clinical diagnosis, previous cytogenetic studies, and probe of interest should be included with the specimen (Call for a list of available probes or see online list.).
This test number is used for tracking oncology FISH specimens to the laboratory. Bill codes will be added when testing is complete, based on the processes performed in the laboratory.
Please provide targeted FISH probe and diagnosis. This test is essentially a tracking code, and the test will only be performed after the probes and diagnosis is provided. Absence of this information will delay turnaround time.
Limitations
Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. |
Specimen Requirements
Specimen
Whole blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei or bone marrow touch preparation slides are acceptable for testing.
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Whole blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei or bone marrow touch preparation slides are acceptable for testing. |
Volume
Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow
Minimum Volume
Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity.
Green-top ( |
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity. |
Collection Instructions
Utilize sterile technique and Labcorp transport kits when possible.
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Utilize sterile technique and Labcorp transport kits when possible. |
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Broken or dirty slides; excessive cellular debris or stained slides; frozen specimen
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 510669 | FISH Oncology | 510670 | Specimen Type | 31208-2 | ||
| 510669 | FISH Oncology | 510671 | Cells Counted | 62361-1 | ||
| 510669 | FISH Oncology | 510672 | Cells Analyzed | 62360-3 | ||
| 510669 | FISH Oncology | 510673 | FISH Result | 62356-1 | ||
| 510669 | FISH Oncology | 510674 | Interpretation | 62365-2 | ||
| 510669 | FISH Oncology | 510638 | Director Review: | 48672-0 | ||
| 510669 | FISH Oncology | 512123 | 11502-2 | |||
| Order Code | 510669 | |||||
| Order Code Name | FISH Oncology | |||||
| Order Loinc | ||||||
| Result Code | 510670 | |||||
| Result Code Name | Specimen Type | |||||
| UofM | ||||||
| Result LOINC | 31208-2 | |||||
| Order Code | 510669 | |||||
| Order Code Name | FISH Oncology | |||||
| Order Loinc | ||||||
| Result Code | 510671 | |||||
| Result Code Name | Cells Counted | |||||
| UofM | ||||||
| Result LOINC | 62361-1 | |||||
| Order Code | 510669 | |||||
| Order Code Name | FISH Oncology | |||||
| Order Loinc | ||||||
| Result Code | 510672 | |||||
| Result Code Name | Cells Analyzed | |||||
| UofM | ||||||
| Result LOINC | 62360-3 | |||||
| Order Code | 510669 | |||||
| Order Code Name | FISH Oncology | |||||
| Order Loinc | ||||||
| Result Code | 510673 | |||||
| Result Code Name | FISH Result | |||||
| UofM | ||||||
| Result LOINC | 62356-1 | |||||
| Order Code | 510669 | |||||
| Order Code Name | FISH Oncology | |||||
| Order Loinc | ||||||
| Result Code | 510674 | |||||
| Result Code Name | Interpretation | |||||
| UofM | ||||||
| Result LOINC | 62365-2 | |||||
| Order Code | 510669 | |||||
| Order Code Name | FISH Oncology | |||||
| Order Loinc | ||||||
| Result Code | 510638 | |||||
| Result Code Name | Director Review: | |||||
| UofM | ||||||
| Result LOINC | 48672-0 | |||||
| Order Code | 510669 | |||||
| Order Code Name | FISH Oncology | |||||
| Order Loinc | ||||||
| Result Code | 512123 | |||||
| Result Code Name | ||||||
| UofM | ||||||
| Result LOINC | 11502-2 |