FKHR Oncology FISH

TEST: 510371
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CPT: Contact CPT coding department at 800-222-7566, ext 6-8400.
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Synonyms

  • Leukemia FISH
  • Lymphoma FISH

Special Instructions

There will be an additional charge for processing paraffin block samples or for samples that require culture.

Expected Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Specimen Requirements

Specimen

Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.

Volume

Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Collection

Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze. Sample must arrive in the laboratory within 72 hours of collection.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen

Test Details

Use

Confirmation/identification of cancer-related alterations (alveolar rhabdomyosarcoma)

Methodology

Fluorescence in situ hybridization (FISH)

Additional Information

A FKHR gene rearrangement is found in alveolar rhabdomyosarcoma (A-RMS). A-RMS is characterized by two pathognomonic translocations which generate gene fusions: t(2;13)(q35;q14) [PAX3-FKHR] and t(1;13)(p36;q14) [PAX7-FKHR], found in 80% and 15% of cases, respectively.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510371 FKHR Oncology FISH 510392 Specimen Type 31208-2
510371 FKHR Oncology FISH 510393 Cells Counted N/A
510371 FKHR Oncology FISH 510394 Cells Analyzed N/A
510371 FKHR Oncology FISH 510366 FISH Result 48674-6
510371 FKHR Oncology FISH 510399 Interpretation 50398-7
510371 FKHR Oncology FISH 510367 Director Review: 48672-0
510371 FKHR Oncology FISH 512123 PDF 51967-8

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