Test Details
Methodology
Chemiluminescent immunoassay
Result Turnaround Time
2 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Dimeric inhibin A (DIA); hCG; pregnancy-associated plasma protein A (PAPP-A)
Use
Screening test in the first trimester of pregnancy for fetal Down syndrome and trisomy 18
Special Instructions
For test inquiries, call CMBP genetic services at 800-345-4363. Client must provide a fetal nuchal translucency (NT) measurement and crown rump length measurement. The NT measurement must be performed by a sonographer credentialed by the Fetal Medicine Foundation or other equivalent entity. The sonographer's credential/certification number must be provided. The following information must also be provided: patient's weight, patient's date of birth, and the number of fetuses. Also indicate relevant patient history (i.e. prior Down syndrome pregnancy, ultrasound anomalies). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening request form (0900). Serum testing is provided from 10.0 to 14.0 weeks' gestation. NT can be assessed when the CRL is 45 to 84 mm.
Limitations
Screening test for Down syndrome and trisomy 18. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a chromosome abnormality is present. This test does not screen for open neural tube defects.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Gel-barrier tube
Collection Instructions
Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.
Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 017500 | First Trimester Screen w/NT | 48798-3 | 017501 | Results | N/A | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017502 | Test Results: | 50679-0 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017503 | Crown Rump Length | mm | 11957-8 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018278 | Crown Rump Length Twin B | mm | 11957-8 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017504 | CRL Scan | 34970-4 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018279 | CRL Scan Twin B | 34970-4 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018280 | Sonographer ID# | 49089-6 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017505 | Gest. Age on Collection Date | weeks | 18185-9 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017506 | Maternal Age At EDD | yr | 43993-5 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017507 | Race | 21484-1 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017508 | Weight | lbs | 29463-7 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018277 | Number of Fetuses | 11878-6 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017577 | Nuchal Translucency | mm | 12146-7 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017512 | Nuchal Translucency MoM | 49035-9 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018281 | NT Twin B | mm | 12146-7 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018282 | NT MoM Twin B | 49035-9 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018178 | Additional US | N/A | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017513 | hCG Value | IU/mL | 19080-1 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017514 | hCG MoM | 32166-1 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018216 | PAPP-A Value | ng/mL | 48407-1 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017516 | PAPP-A MoM | 76348-2 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017535 | DIA Value | pg/mL | 23883-2 |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017518 | DIA MoM | 36904-1 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018079 | Down Syndrome | 43995-0 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018080 | Down Syndrome | 49090-4 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018081 | Trisomy 18 | 43994-3 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018082 | Trisomy 18 | 47223-3 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017523 | Down Syndrome Interpretation | 50679-0 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017524 | Trisomy 18 Interpretation | 50679-0 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 017532 | Comments | 77202-0 | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 018078 | Note: | N/A | |
| 017500 | First Trimester Screen w/NT | 48798-3 | 511933 | 11502-2 | ||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017501 | |||||
| Result Code Name | Results | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017502 | |||||
| Result Code Name | Test Results: | |||||
| UofM | ||||||
| Result LOINC | 50679-0 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017503 | |||||
| Result Code Name | Crown Rump Length | |||||
| UofM | mm | |||||
| Result LOINC | 11957-8 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018278 | |||||
| Result Code Name | Crown Rump Length Twin B | |||||
| UofM | mm | |||||
| Result LOINC | 11957-8 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017504 | |||||
| Result Code Name | CRL Scan | |||||
| UofM | ||||||
| Result LOINC | 34970-4 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018279 | |||||
| Result Code Name | CRL Scan Twin B | |||||
| UofM | ||||||
| Result LOINC | 34970-4 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018280 | |||||
| Result Code Name | Sonographer ID# | |||||
| UofM | ||||||
| Result LOINC | 49089-6 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017505 | |||||
| Result Code Name | Gest. Age on Collection Date | |||||
| UofM | weeks | |||||
| Result LOINC | 18185-9 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017506 | |||||
| Result Code Name | Maternal Age At EDD | |||||
| UofM | yr | |||||
| Result LOINC | 43993-5 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017507 | |||||
| Result Code Name | Race | |||||
| UofM | ||||||
| Result LOINC | 21484-1 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017508 | |||||
| Result Code Name | Weight | |||||
| UofM | lbs | |||||
| Result LOINC | 29463-7 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018277 | |||||
| Result Code Name | Number of Fetuses | |||||
| UofM | ||||||
| Result LOINC | 11878-6 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017577 | |||||
| Result Code Name | Nuchal Translucency | |||||
| UofM | mm | |||||
| Result LOINC | 12146-7 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017512 | |||||
| Result Code Name | Nuchal Translucency MoM | |||||
| UofM | ||||||
| Result LOINC | 49035-9 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018281 | |||||
| Result Code Name | NT Twin B | |||||
| UofM | mm | |||||
| Result LOINC | 12146-7 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018282 | |||||
| Result Code Name | NT MoM Twin B | |||||
| UofM | ||||||
| Result LOINC | 49035-9 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018178 | |||||
| Result Code Name | Additional US | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017513 | |||||
| Result Code Name | hCG Value | |||||
| UofM | IU/mL | |||||
| Result LOINC | 19080-1 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017514 | |||||
| Result Code Name | hCG MoM | |||||
| UofM | ||||||
| Result LOINC | 32166-1 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018216 | |||||
| Result Code Name | PAPP-A Value | |||||
| UofM | ng/mL | |||||
| Result LOINC | 48407-1 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017516 | |||||
| Result Code Name | PAPP-A MoM | |||||
| UofM | ||||||
| Result LOINC | 76348-2 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017535 | |||||
| Result Code Name | DIA Value | |||||
| UofM | pg/mL | |||||
| Result LOINC | 23883-2 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017518 | |||||
| Result Code Name | DIA MoM | |||||
| UofM | ||||||
| Result LOINC | 36904-1 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018079 | |||||
| Result Code Name | Down Syndrome | |||||
| UofM | ||||||
| Result LOINC | 43995-0 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018080 | |||||
| Result Code Name | Down Syndrome | |||||
| UofM | ||||||
| Result LOINC | 49090-4 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018081 | |||||
| Result Code Name | Trisomy 18 | |||||
| UofM | ||||||
| Result LOINC | 43994-3 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018082 | |||||
| Result Code Name | Trisomy 18 | |||||
| UofM | ||||||
| Result LOINC | 47223-3 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017523 | |||||
| Result Code Name | Down Syndrome Interpretation | |||||
| UofM | ||||||
| Result LOINC | 50679-0 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017524 | |||||
| Result Code Name | Trisomy 18 Interpretation | |||||
| UofM | ||||||
| Result LOINC | 50679-0 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 017532 | |||||
| Result Code Name | Comments | |||||
| UofM | ||||||
| Result LOINC | 77202-0 | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 018078 | |||||
| Result Code Name | Note: | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 017500 | |||||
| Order Code Name | First Trimester Screen w/NT | |||||
| Order Loinc | 48798-3 | |||||
| Result Code | 511933 | |||||
| Result Code Name | ||||||
| UofM | ||||||
| Result LOINC | 11502-2 |