Test Details
Methodology
Fluorescence in situ hybridization (FISH)
Result Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This test is used for confirmation/identification of cancer-related alterations (for lung and brain cancer).
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This test is used for confirmation/identification of cancer-related alterations (for lung and brain cancer). |
Special Instructions
There will be an additional charge for processing paraffin block samples or for samples that require culture.
Limitations
Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
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Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. |
Custom Additional Information
High EGFR copy number or ratio of EGFR:control >2.0 detected by FISH has been shown to correlate with response, progression-free survival, and overall survival after treatment with EGFR TKIs in patients with non−small-cell lung cancer (NSCLC).1
Specimen Requirements
Specimen
FFPE slides with tumor, whole blood or paraffin block (acceptable at an additional charge)
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FFPE slides with tumor, whole blood or paraffin block (acceptable at an additional charge) |
Volume
Three slides 4- or 5-micron thick with tumor or 5 mL whole blood
Three slides |
Three slides 4- or 5-micron thick with tumor or 5 mL whole blood |
Minimum Volume
Two slides 4- or 5-micron thick on positively charged slides or 1 mL whole blood (Note: Minimum volumes may not allow for repeat testing.)
Two slides |
Two slides 4- or 5-micron thick on positively charged slides or 1 mL whole blood (Note: Minimum volumes may not allow for repeat testing.) |
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal
Collection Instructions
Utilize sterile technique and Labcorp transport kits when possible.
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Utilize sterile technique and Labcorp transport kits when possible. |
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen; no tumor submitted
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 510355 | EGFR Oncology FISH | 511736 | Specimen Type | 31208-2 | ||
| 510355 | EGFR Oncology FISH | 511737 | Cells Counted | 62361-1 | ||
| 510355 | EGFR Oncology FISH | 511738 | Cells Analyzed | 62360-3 | ||
| 510355 | EGFR Oncology FISH | 510353 | FISH Result | 48674-6 | ||
| 510355 | EGFR Oncology FISH | 511739 | Interpretation | 62365-2 | ||
| 510355 | EGFR Oncology FISH | 510356 | Director Review: | 48672-0 | ||
| 510355 | EGFR Oncology FISH | 512123 | 11502-2 | |||
| Order Code | 510355 | |||||
| Order Code Name | EGFR Oncology FISH | |||||
| Order Loinc | ||||||
| Result Code | 511736 | |||||
| Result Code Name | Specimen Type | |||||
| UofM | ||||||
| Result LOINC | 31208-2 | |||||
| Order Code | 510355 | |||||
| Order Code Name | EGFR Oncology FISH | |||||
| Order Loinc | ||||||
| Result Code | 511737 | |||||
| Result Code Name | Cells Counted | |||||
| UofM | ||||||
| Result LOINC | 62361-1 | |||||
| Order Code | 510355 | |||||
| Order Code Name | EGFR Oncology FISH | |||||
| Order Loinc | ||||||
| Result Code | 511738 | |||||
| Result Code Name | Cells Analyzed | |||||
| UofM | ||||||
| Result LOINC | 62360-3 | |||||
| Order Code | 510355 | |||||
| Order Code Name | EGFR Oncology FISH | |||||
| Order Loinc | ||||||
| Result Code | 510353 | |||||
| Result Code Name | FISH Result | |||||
| UofM | ||||||
| Result LOINC | 48674-6 | |||||
| Order Code | 510355 | |||||
| Order Code Name | EGFR Oncology FISH | |||||
| Order Loinc | ||||||
| Result Code | 511739 | |||||
| Result Code Name | Interpretation | |||||
| UofM | ||||||
| Result LOINC | 62365-2 | |||||
| Order Code | 510355 | |||||
| Order Code Name | EGFR Oncology FISH | |||||
| Order Loinc | ||||||
| Result Code | 510356 | |||||
| Result Code Name | Director Review: | |||||
| UofM | ||||||
| Result LOINC | 48672-0 | |||||
| Order Code | 510355 | |||||
| Order Code Name | EGFR Oncology FISH | |||||
| Order Loinc | ||||||
| Result Code | 512123 | |||||
| Result Code Name | ||||||
| UofM | ||||||
| Result LOINC | 11502-2 |