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EGFR Oncology FISH

CPT

Contact CPT coding department at 800-222-7566, ext. 6-8400.

Synonyms
  • Brain Cancer
  • Breast Cancer
  • Lung Cancer
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  • Updated on 03/31/2025

Test Details

Methodology

Fluorescence in situ hybridization (FISH)

Result Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Use

This test is used for confirmation/identification of cancer-related alterations (for lung and brain cancer).

Confirmation/identification of cancer-related alterations (for lung and brain cancer)

This test is used for confirmation/identification of cancer-related alterations (for lung and brain cancer).

Special Instructions

There will be an additional charge for processing paraffin block samples or for samples that require culture.

Limitations

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Footnotes

1. Cappuzzo F, Hirsch FR, Rossi E, et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 2005 May 4; 97(9):643-655.17317677

Custom Additional Information

High EGFR copy number or ratio of EGFR:control >2.0 detected by FISH has been shown to correlate with response, progression-free survival, and overall survival after treatment with EGFR TKIs in patients with non−small-cell lung cancer (NSCLC).1

Specimen Requirements

Specimen

FFPE slides with tumor, whole blood or paraffin block (acceptable at an additional charge)

Three slides of 4- or 5-micron FFPE sections with tumor. Blood or paraffin block (acceptable at an additional charge).

FFPE slides with tumor, whole blood or paraffin block (acceptable at an additional charge)

Volume

Three slides 4- or 5-micron thick with tumor or 5 mL whole blood

Three slides of 4- or 5-micron thick with tumor or 10 mL blood (adult), 5 mL blood (pediatric)

Three slides 4- or 5-micron thick with tumor or 5 mL whole blood

Minimum Volume

Two slides 4- or 5-micron thick on positively charged slides or 1 mL whole blood (Note: Minimum volumes may not allow for repeat testing.)

Two slides of 4- or 5-micron thick with tumor or 5 mL blood (adult), 1 mL blood (pediatric)

Two slides 4- or 5-micron thick on positively charged slides or 1 mL whole blood (Note: Minimum volumes may not allow for repeat testing.)

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal

Collection Instructions

Utilize sterile technique and Labcorp transport kits when possible.

Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.

Utilize sterile technique and Labcorp transport kits when possible.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen; no tumor submitted

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510355 EGFR Oncology FISH 511736 Specimen Type 31208-2
510355 EGFR Oncology FISH 511737 Cells Counted 62361-1
510355 EGFR Oncology FISH 511738 Cells Analyzed 62360-3
510355 EGFR Oncology FISH 510353 FISH Result 48674-6
510355 EGFR Oncology FISH 511739 Interpretation 62365-2
510355 EGFR Oncology FISH 510356 Director Review: 48672-0
510355 EGFR Oncology FISH 512123 PDF 11502-2
Order Code510355
Order Code NameEGFR Oncology FISH
Order Loinc
Result Code511736
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code510355
Order Code NameEGFR Oncology FISH
Order Loinc
Result Code511737
Result Code NameCells Counted
UofM
Result LOINC62361-1
Order Code510355
Order Code NameEGFR Oncology FISH
Order Loinc
Result Code511738
Result Code NameCells Analyzed
UofM
Result LOINC62360-3
Order Code510355
Order Code NameEGFR Oncology FISH
Order Loinc
Result Code510353
Result Code NameFISH Result
UofM
Result LOINC48674-6
Order Code510355
Order Code NameEGFR Oncology FISH
Order Loinc
Result Code511739
Result Code NameInterpretation
UofM
Result LOINC62365-2
Order Code510355
Order Code NameEGFR Oncology FISH
Order Loinc
Result Code510356
Result Code NameDirector Review:
UofM
Result LOINC48672-0
Order Code510355
Order Code NameEGFR Oncology FISH
Order Loinc
Result Code512123
Result Code NamePDF
UofM
Result LOINC11502-2