Find Locations
For hours, walk-ins and appointments.Synonyms
- DNA Histogram, Paraffin
Test Includes
DNA index; histogram interpretation
Special Instructions
Please direct any questions regarding this test to oncology customer service at 800-345-4363.
Expected Turnaround Time
5 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Specimen Requirements
Specimen
Formalin-fixed, paraffin-embedded (FFPE) tumor (tissue block)
Volume
One paraffin block
Container
Paraffin block transport pouch
Collection
Specimen should be fixed in 10% neutral-buffered formalin. Optimum fixation time is 12 to 24 hours, not to exceed 48 hours.
Storage Instructions
Maintain specimen at room temperature.
Test Details
Use
Cancer prognosis. In general, aneuploid tumors have an unfavorable prognosis compared to diploid tumors.
Limitations
Use of fixatives other than formalin may not yield equivalent or satisfactory results. No % S phase is reported for tumors analyzed by image cytometry. Small biopsies require image analysis of a 6-μ tissue section. This test is not a diagnostic test for cancer.
Methodology
Flow cytometry
Additional Information
The DNA index is a measure of the nuclear DNA content of tumor cells compared to normal cells. Tumors with abnormal DNA content are termed DNA aneuploid while those with DNA content equal to normal cells are termed DNA diploid.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 480327 | DNA Ploidy, Paraffin Block | 487018 | Tissue Site | N/A | ||
| 480327 | DNA Ploidy, Paraffin Block | 487002 | Specimen Received | N/A | ||
| 480327 | DNA Ploidy, Paraffin Block | 487003 | Method of Analysis | N/A | ||
| 480327 | DNA Ploidy, Paraffin Block | 487004 | DNA Index (Population 1) | 30912-0 | ||
| 480327 | DNA Ploidy, Paraffin Block | 487017 | S Phase Interpretation | N/A | ||
| 480327 | DNA Ploidy, Paraffin Block | 487012 | Ploidy Interpretation | N/A | ||
| 480327 | DNA Ploidy, Paraffin Block | 487026 | Director Review | 72486-4 |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf