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- Diphtheria Antibodies
- Diphtheria Toxin Antibodies
Expected Turnaround Time
1 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.25 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | Unstable |
Causes for Rejection
Gross hemolysis; lipemia; bacterial contamination
Test Details
Use
Assess immunity against diphtheria by determining levels of circulating antibodies to diphtheria toxin or to measure the immune response, postvaccination, in individuals suspected of immunodeficiency disorders
Limitations
This procedure is rarely used for confirmation of diphtheria infection; it cannot accurately discriminate antibodies between 0.10 IU/mL and 0.01 IU/mL. Immunity declines with age.
This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.
Methodology
Enzyme immunoassay (EIA)
Reference Interval
• Nonprotective: <0.1 IU/mL
• Protective: ≥0.1 IU/mL
References
Rose NR, Manual of Clinical Immunology, 5th ed, Washington, DC: ASM Press, 1997, 465-9.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 163709 | Diphtheria Antitoxoid Ab | 5116-9 | 163710 | Diphtheria Antitoxoid Ab | IU/mL | 5116-9 |
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