Test Details
Methodology
Lateral flow immunochromographic assay
Result Turnaround Time
1 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Reflex to titer on positive result
Use
Aid in establishing the presence of Cryptococcus neoformans or Cryptococcus gattii infection
Limitations
Endpoint titers may not correlate between different methods of cryptococcal antigen testing. Patients with positive cryptococcal antigen results, therefore, should be monitored using the same assay.
References
Custom Additional Information
Published data for the median sensitivity and specificity for serum specimens are 100% and 99.5%, respectively. False-positive results due to the presence of rheumatoid factor have not been noted with the cryptococcal antigen lateral flow immunochromatographic assay. A negative test does not preclude diagnosis of Cryptococcus infection, particularly if only a single specimen has been tested and the patient shows symptoms consistent with cryptococcosis.
Specimen Requirements
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Stability Requirements
Temperature | Period |
|---|---|
Refrigerated | 72 hours (stability provided by manufacturer or literature reference) |
Frozen | >72 hours (stability provided by manufacturer or literature reference) |
Storage Instructions
Refrigerated (2°-8°C) or frozen (<−20°C)
Causes for Rejection
Quantity not sufficient for analysis; inappropriate specimen source; inappropriate specimen collection device; hemolysis; lipemia; specimen stability exceeded; name discrepancy between the name on the specimen container and the name in the computer or on the test request form
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 183025 | Cryptococcus Antigen, Serum | 70910-5 | 183026 | Cryptococcus Antigen, Serum | 70910-5 | |
| Order Code | 183025 | |||||
| Order Code Name | Cryptococcus Antigen, Serum | |||||
| Order Loinc | 70910-5 | |||||
| Result Code | 183026 | |||||
| Result Code Name | Cryptococcus Antigen, Serum | |||||
| UofM | ||||||
| Result LOINC | 70910-5 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 183036 | Cryptococcus Ag Titer, Serum | 183036 | Cryptococcus Ag Titer, Serum | 9818-6 | |
| Reflex 1 | ||||||
| Order Code | 183036 | |||||
| Order Name | Cryptococcus Ag Titer, Serum | |||||
| Result Code | 183036 | |||||
| Result Name | Cryptococcus Ag Titer, Serum | |||||
| UofM | ||||||
| Result LOINC | 9818-6 | |||||