Test Details
Methodology
Visual observation of refrigerated samples
Result Turnaround Time
4 - 8 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Qualitative test for cryoglobulin; reflex quantitation (as percentage) and immunofixation of cryoprecipitate if positive
Use
Cryoglobulins may be present in macroglobulinemia of Waldenström, myeloma, chronic lymphocytic leukemia, lupus, chronic active hepatitis, and other viral infections.
Custom Additional Information
These are proteins that precipitate from blood at low temperatures. A precipitate from serum that forms overnight at 4°C and dissolves at 37°C is called a cryoglobulin.
Cryoglobulins may be divided into three classes. Type I are monoclonal immunoglobulins and are usually associated with lymphoproliferative disorders. Type II are mixtures of a monoclonal IgM and polyclonal IgG, and are associated with macroglobulinemia and chronic active hepatitis. Type III are mixtures of polyclonal IgM and polyclonal IgG. These are found in a wide variety of disorders.
A high percentage of patients with cryoglobulinemia have clinical symptoms, and of these the most common are vascular (ie, purpura and digital necrosis). Raynaud phenomenon is also common.
Patients with SLE who are rheumatoid factor-negative but cryoglobulin-positive are more likely to develop renal disease than those who are rheumatoid factor-positive and cryoglobulin-negative.
Specimen Requirements
Specimen
Serum, prewarmed
Volume
3 mL
Minimum Volume
2 mL
Container
Red-top tube (no gel)
Collection Instructions
Specimen must be drawn in a prewarmed tube and kept at 37°C while clotting. Separate serum from cells immediately after clot formation (keep at 37°C while clotting), and transfer serum into a clean transport tube. Label transport tube "Prewarmed."
Reference Range
None detected (positives are reported as percentages)
Storage Instructions
Room temperature
Patient Preparation
Patient should be fasting.
Causes for Rejection
Specimen not allowed to clot at 37°C; patient not fasting; lipemia; gel-barrier tube used for collection; whole blood received
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 001594 | Cryoglobulin, Ql, Serum, Rflx | 12201-0 | 001595 | Cryoglobulin, Ql, Serum, Rflx | 12201-0 | |
| Order Code | 001594 | |||||
| Order Code Name | Cryoglobulin, Ql, Serum, Rflx | |||||
| Order Loinc | 12201-0 | |||||
| Result Code | 001595 | |||||
| Result Code Name | Cryoglobulin, Ql, Serum, Rflx | |||||
| UofM | ||||||
| Result LOINC | 12201-0 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 001686 | Immunofixation Elect | 001681 | Cryoglobulin % | % | 15174-6 |
| Reflex 1 | ||||||
| Order Code | 001686 | |||||
| Order Name | Immunofixation Elect | |||||
| Result Code | 001681 | |||||
| Result Name | Cryoglobulin % | |||||
| UofM | % | |||||
| Result LOINC | 15174-6 | |||||
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 001686 | Immunofixation Elect | 001684 | IFE Result, Cryoprecipitant | 48638-1 | |
| Reflex 1 | ||||||
| Order Code | 001686 | |||||
| Order Name | Immunofixation Elect | |||||
| Result Code | 001684 | |||||
| Result Name | IFE Result, Cryoprecipitant | |||||
| UofM | ||||||
| Result LOINC | 48638-1 | |||||