Clorazepate, Serum or Plasma

TEST: 007930
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CPT: 80299
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Synonyms

  • Tranxene® SD™
  • Tranxene® T-Tab®

Expected Turnaround Time

2 - 4 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Serum or plasma

Volume

1 mL

Minimum Volume

0.4 mL

Container

Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

Collection

Transfer separated serum or plasma to a plastic transport tube. Specimen should be collected prior to next dose unless otherwise noted.

Storage Instructions

Refrigerate.

Causes for Rejection

Gel-barrier tube

Test Details

Use

Evaluate toxicity; monitor therapeutic levels

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

Therapeutic: 0.5−2.0 μg/mL (reported as nordiazepam)

Critical Value

Potentially toxic: >5.0 μg/mL (reported as nordiazepam)

Additional Information

The drug is used in the treatment of general anxiety disorder, the management of ethanol withdrawal, and as an adjunct anticonvulsant drug. Half-life of elimination: 40 to 50 hours. Time to peak serum: approximately one hour.

References

American Medical Association, Division of Drugs and Toxicology. Drug Evaluations Subscription. Chicago, Ill:: AMA; Summer 1991.
Drug Information Handbook. 24th ed. Hudson, OH: Wolters Kluwer Clinical Drug Information, Inc; 2015; 487.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
007930 Clorazepate (Tranxene(R)), S 3498-3 007930 Clorazepate (Tranxene(R)), S ug/mL 3498-3

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