Test Details
Methodology
Cytogenetics; fluorescence in situ hybridization (FISH)
Result Turnaround Time
7 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
BCR-ABL for chronic myelogenous leukemia (CML), FISH; chromosome analysis; quantitative monitoring for CML by FISH; ABL deletions are confirmed by linked ASS analysis.
Use
This test is used to confirm the diagnosis of chronic myelogenous leukemia, establish the chronic-phase karyotype for comparison with blast crisis alterations and monitor residual disease.
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This test is used to confirm the diagnosis of chronic myelogenous leukemia, establish the chronic-phase karyotype for comparison with blast crisis alterations and monitor residual disease. |
Special Instructions
Include pertinent clinical diagnosis and previous cytogenetic studies on the test request form.
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Include pertinent clinical diagnosis and previous cytogenetic studies on the test request form.
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Limitations
Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. |
Specimen Requirements
Specimen
Bone marrow or whole blood
Bone marrow or peripheral |
Bone marrow or whole blood |
Volume
2 mL bone marrow or 3 mL whole blood
2 mL bone marrow or 3 mL peripheral |
2 mL bone marrow or 3 mL whole blood |
Minimum Volume
1 mL whole blood or 1 mL bone marrow (Note: Minimum volumes may not allow for repeat testing.)
1 mL whole blood or 1 mL bone marrow (Note: Minimum volumes may not allow for repeat testing.) |
Container
Green-top (sodium heparin) tube
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Green-top (sodium heparin) tube |
Collection Instructions
Utilize sterile technique and Labcorp transport kits when possible.
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Utilize sterile technique and Labcorp transport kits when possible. |
Storage Instructions
Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.
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Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze. |
Causes for Rejection
Broken Vacutainer®; broken or stained slides; decalcified bone core; frozen specimen; quantity not sufficient for analysis
Broken Vacutainer®; broken or stained slides; decalcified bone core; frozen specimen; quantity not sufficient for analysis |
LOINC® Map
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
150500 | CML Chromosome/FISH Profile | 150414 | Cells Counted | 62361-1 | ||
150500 | CML Chromosome/FISH Profile | 150415 | Cells Analyzed | 62360-3 | ||
150500 | CML Chromosome/FISH Profile | 150416 | FISH Result | 51867-0 | ||
150500 | CML Chromosome/FISH Profile | 510977 | Interpretation | 50398-7 | ||
150500 | CML Chromosome/FISH Profile | 150418 | Specimen Type | 31208-2 | ||
150500 | CML Chromosome/FISH Profile | 510978 | Director Review: | 48672-0 | ||
150500 | CML Chromosome/FISH Profile | 512123 | 11502-2 | |||
150500 | CML Chromosome/FISH Profile | 510678 | Specimen Type | 31208-2 | ||
150500 | CML Chromosome/FISH Profile | 510679 | Cells Counted | 62361-1 | ||
150500 | CML Chromosome/FISH Profile | 510680 | Cells Analyzed | 62360-3 | ||
150500 | CML Chromosome/FISH Profile | 510681 | Cells Karyotyped | 55199-4 | ||
150500 | CML Chromosome/FISH Profile | 510682 | GTG Band Resolution Achieved | 62358-7 | ||
150500 | CML Chromosome/FISH Profile | 510683 | Cytogenetic Result | 62356-1 | ||
150500 | CML Chromosome/FISH Profile | 510992 | Interpretation | 62365-2 | ||
150500 | CML Chromosome/FISH Profile | 510993 | Director Review: | 48672-0 | ||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 150414 | |||||
Result Code Name | Cells Counted | |||||
UofM | ||||||
Result LOINC | 62361-1 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 150415 | |||||
Result Code Name | Cells Analyzed | |||||
UofM | ||||||
Result LOINC | 62360-3 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 150416 | |||||
Result Code Name | FISH Result | |||||
UofM | ||||||
Result LOINC | 51867-0 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510977 | |||||
Result Code Name | Interpretation | |||||
UofM | ||||||
Result LOINC | 50398-7 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 150418 | |||||
Result Code Name | Specimen Type | |||||
UofM | ||||||
Result LOINC | 31208-2 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510978 | |||||
Result Code Name | Director Review: | |||||
UofM | ||||||
Result LOINC | 48672-0 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 512123 | |||||
Result Code Name | ||||||
UofM | ||||||
Result LOINC | 11502-2 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510678 | |||||
Result Code Name | Specimen Type | |||||
UofM | ||||||
Result LOINC | 31208-2 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510679 | |||||
Result Code Name | Cells Counted | |||||
UofM | ||||||
Result LOINC | 62361-1 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510680 | |||||
Result Code Name | Cells Analyzed | |||||
UofM | ||||||
Result LOINC | 62360-3 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510681 | |||||
Result Code Name | Cells Karyotyped | |||||
UofM | ||||||
Result LOINC | 55199-4 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510682 | |||||
Result Code Name | GTG Band Resolution Achieved | |||||
UofM | ||||||
Result LOINC | 62358-7 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510683 | |||||
Result Code Name | Cytogenetic Result | |||||
UofM | ||||||
Result LOINC | 62356-1 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510992 | |||||
Result Code Name | Interpretation | |||||
UofM | ||||||
Result LOINC | 62365-2 | |||||
Order Code | 150500 | |||||
Order Code Name | CML Chromosome/FISH Profile | |||||
Order Loinc | ||||||
Result Code | 510993 | |||||
Result Code Name | Director Review: | |||||
UofM | ||||||
Result LOINC | 48672-0 |