Chronic Myelogenous Leukemia (CML) Profile: Chromosome Analysis and BCR-ABL, FISH

Test Number 150500

CPT

Contact CPT coding department at 800-222-7566, ext 6-8400. If reflex testing is performed, concomitant CPT codes/charges will apply.

Synonyms

BCR-ABL FISH and Chromosome Analysis
Chromosome Analysis and BCR-ABL FISH
Philadelphia Chromosome

Test Details

Methodology

Cytogenetics; fluorescence in situ hybridization (FISH)

Result Turnaround Time

7 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Test Includes

BCR-ABL for chronic myelogenous leukemia (CML), FISH; chromosome analysis; quantitative monitoring for CML by FISH; ABL deletions are confirmed by linked ASS analysis.

Use

This test is used to confirm the diagnosis of chronic myelogenous leukemia, establish the chronic-phase karyotype for comparison with blast crisis alterations and monitor residual disease.

~~Confirm the diagnosis of chronic myelogenous leukemia; establish the chronic-phase karyotype for comparison with blast crisis alterations; monitor residual disease~~

This test is used to confirm the diagnosis of chronic myelogenous leukemia, establish the chronic-phase karyotype for comparison with blast crisis alterations and monitor residual disease.

Special Instructions

Include pertinent clinical diagnosis and previous cytogenetic studies on the test request form.

Please direct any questions regarding this test to oncology customer service at 800-345-4363. Please note that the chromosome portion of this profile is generally not successful on peripheral blood samples from CML patients receiving imatinib (Gleevec®).

Include pertinent clinical diagnosis and previous cytogenetic studies on the test request form.

Limitations

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Bone marrow or whole blood

~~Bone marrow or peripheral blood~~

Bone marrow or whole blood

Volume

2 mL bone marrow or 3 mL whole blood

~~2 mL bone marrow or 3 mL peripheral blood~~

2 mL bone marrow or 3 mL whole blood

Minimum Volume

1 mL bone marrow or 1 mL whole blood (Note: Minimum volumes may not allow for repeat testing.)

Container

Green-top (sodium heparin) tube

~~Pediatric green-top (~~heparin) tube

Green-top (sodium heparin) tube

Collection Instructions

Utilize sterile technique and Labcorp transport kits when possible.

Submit at room temperature using Leukemia/Lymphoma Specimen Transport Kit (supplied by LabCorp). Specimens should arrive in the laboratory within 48 hours of collection. Indicate date and time of collection on the test request form.

Utilize sterile technique and Labcorp transport kits when possible.

Storage Instructions

Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.

~~Maintain specimen at room temperatur~~e.