Find Locations
For hours, walk-ins and appointments.CHOP Oncology FISH
CPT:
Contact CPT coding department at 800-222-7566, ext. 6-8400.
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Contact CPT coding department at 800-222-7566, ext. 6-8400. |
Synonyms
- Leukemia FISH
- Lymphoma FISH
Special Instructions
There will be an additional charge for processing paraffin block samples or for samples that require culture.
Expected Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Specimen Requirements
Specimen
Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.
Volume
Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow
Minimum Volume
Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube
Collection
Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen
Test Details
Use
This test is used for confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas).
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This test is used for confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas). |
Methodology
Fluorescence in situ hybridization (FISH)
Additional Information
The CHOP break-apart FISH probe is designed to rule out a rearrangement of the gene located at 12q13 associated with a reciprocal (12;16)(q13;p11) translocation (CHOP-TLS gene fusion) and myxoid/round cell liposarcoma. CHOP is fused to TLS in about 90% of myxoid liposarcomas/round cell liposarcomas.
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