Find Locations
For hours, walk-ins and appointments.Celiac Antibodies tTG IgA, EMA IgA, Total IgA With Reflex to tTG IgG
CPT:
82784; 86231; 86364. If reflex testing is performed, concomitant CPT codes/charges will apply.
Synonyms
- Endomysial Antibodies
- Tissue Transglutaminase (tTG) Antibodies
Test Includes
Endomysial antibody, IgA; tissue transglutaminase (tTG), IgA; total IgA; reflex to tissue transglutaminase (tTG), IgG
Special Instructions
Reflex testing for tissue transglutaminase (tTG) IgG antibodies is performed if total IgA is decreased.
Expected Turnaround Time
3 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1.75 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
Test Details
Use
Aid in the diagnosis of gluten-sensitive enteropathies
Methodology
Enzyme immunoassay (EIA); indirect immunofluorescence
Additional Information
Celiac disease is a gluten enteropathy occurring in both children and adults. The disease is probably underdiagnosed in that it may affect as much as 1% of the population in the US. The condition is characterized by a sensitivity to gluten (found in wheat, barley, and rye) that causes inflammation and atrophy of the villi of the small intestine, malabsorption, etc. This sensitivity to gluten may also be seen in dermatitis herpetiformis. Strict avoidance of gluten in the diet will control disease activity, and antibodies to serum markers will disappear with time.
References
Baigi F, Pezzimenti D, Campanella J, et al. Endomysial and tissue transglutaminase antibodies in coeliac sera: A comparison not influenced by previous serological testing. Scand J Gastroenterol. 2001 Sep; 36(9):955-958. 11521986
Bürgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug; 66(8):941-947. 1819255
Calabuig M, Torregosa R, Polo P, et al. Serological markers and celiac disease: A new diagnostic approach? Pediatr Gastroenterol Nutr. 1990 May; 10(4):435-442. 2193137
Green PH, Jabri B. Coeliac disease. Lancet. 2003 Aug 2; 362(9381):383-391. 12907013
National Institutes of Health Consensus Development Conference Statement on Celiac Disease, 2004.
Pruessner HT. Detecting celiac disease in your patients. Am Fam Physician. 1998 Mar 1; 57(5):1023-1034, 1039-1041. 9518950
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 165142 | Celiac Disease Panel | 94494-2 | 164997 | Endomysial Antibody IgA | 10362-2 | |
| 165142 | Celiac Disease Panel | 94494-2 | 164643 | t-Transglutaminase (tTG) IgA | U/mL | 31017-7 |
| 165142 | Celiac Disease Panel | 94494-2 | 001784 | Immunoglobulin A, Qn, Serum | mg/dL | 2458-8 |
| Reflex Table for Immunoglobulin A, Qn, Serum | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 164988 | t-Transglutaminase (tTG) IgG | 164989 | t-Transglutaminase (tTG) IgG | U/mL | 32998-7 |
© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.
CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf