Celiac Antibodies Profile tTG IgA, tTG IgG, DGP IgA, DGP IgG, EMA IgA, and Total IgA

TEST: 165126
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CPT: 82784; 86231; 86258(x2); 86364(x2)
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Synonyms

  • Deamidated Gliadin
  • Endomysial IgA Antibodies

Test Includes

Deamidated gliadin antibodies; endomysial antibodies; tissue transglutaminase (tTG) antibodies; total IgA

Expected Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Celiac Disease Testing Services

    Specimen Requirements

    Specimen

    Serum

    Volume

    3 mL

    Minimum Volume

    2.25 mL (Note: This volume does not allow for repeat testing.)

    Container

    Red-top tube or gel-barrier tube

    Storage Instructions

    Room temperature

    Stability Requirements

    Temperature

    Period

    Room temperature

    14 days

    Refrigerated

    14 days

    Frozen

    14 days

    Freeze/thaw cycles

    Stable x3

    Causes for Rejection

    Hemolysis; lipemia; gross bacterial contamination

    Test Details

    Use

    Aid in the diagnosis of gluten-sensitive enteropathies

    Methodology

    Enzyme immunoassay (EIA); indirect immunofluorescence

    Additional Information

    Celiac disease is a gluten enteropathy occurring in both children and adults. The disease is probably underdiagnosed in that it may affect as much as 1% of the population in the US. The condition is characterized by a sensitivity to gluten (found in wheat, barley, and rye) that causes inflammation and atrophy of the villi of the small intestine, malabsorption, etc. This sensitivity to gluten may also be seen in dermatitis herpetiformis. Strict avoidance of gluten in the diet will control disease activity, and antibodies to serum markers will disappear with time.

    References

    Agardh D. Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin Gastroenterol Hepatol. 2007 Nov; 5(11):1276-1281. 17683995
    Baigi F, Pezzimenti D, Campanella J, et al. Endomysial and tissue transglutaminase antibodies in coeliac sera: A comparison not influenced by previous serological testing. Scand J Gastroenterol. 2001 Sep; 36(9):955-958. 11521986
    Bürgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug; 66(8):941-947. 1819255
    Calabuig M, Torregosa R, Polo P, et al. Serological markers and celiac disease: A new diagnostic approach? Pediatr Gastroenterol Nutr. 1990 May; 10(4):435-442. 2193137
    Green PH, Jabri B. Coeliac disease. Lancet. 2003 Aug 2; 362(9381):383-391.12907013
    Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005 Jan; 40(1):1-19. 15625418
    Kaukinen K, Collin P, Laurila K, Kaartinen T, Partanen J, Mäki M. Resurrection of gliadin antibodies in coeliac disease. Deamidated gliadin peptide antibody test provides additional diagnostic benefit. Scand J Gastroenterol. 2007 Dec; 42(12):1428-1433. 17852878
    National Institutes of Health Consensus Development Conference Statement on Celiac Disease, 2004.
    Pruessner HT. Detecting celiac disease in your patients. Am Fam Physician. 1998 Mar 1; 57(5):1023-1034, 1039-1041. 9518950

    LOINC® Map

    Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
    165126 Celiac Disease Comprehensive 94493-4 161652 Deamidated Gliadin Abs, IgA units 58709-7
    165126 Celiac Disease Comprehensive 94493-4 161693 Deamidated Gliadin Abs, IgG units 58710-5
    165126 Celiac Disease Comprehensive 94493-4 164643 t-Transglutaminase (tTG) IgA U/mL 31017-7
    165126 Celiac Disease Comprehensive 94493-4 164989 t-Transglutaminase (tTG) IgG U/mL 32998-7
    165126 Celiac Disease Comprehensive 94493-4 164997 Endomysial Antibody IgA 10362-2
    165126 Celiac Disease Comprehensive 94493-4 001784 Immunoglobulin A, Qn, Serum mg/dL 2458-8

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