Test Details
Methodology
Immunologic
Result Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Apo A-1 comprises 60% to 70% of the protein content of HDL. Apo A-1 serves as an activator of LCAT which is involved in the transport of cholesterol from peripheral tissues to the liver where it is degraded. Decreased serum HDL cholesterol levels have been reported to correlate with increased risk of coronary artery disease (CAD); however, Apo A-1 has been suggested as a better discrimination of CAD than HDL.1 Apo A-1 levels also correlate with survival rates or risk factors for patients with myocardial infarction and peripheral vascular disease. Measurement of Apo A-1 may also aid in the diagnosis of Tangier disease (absence of alpha-lipoprotein).
Special Instructions
State patient's sex on the test request form.
Footnotes
References
Specimen Requirements
Specimen
Serum (preferred) or plasma
Volume
2 mL
Container
Red-top tube, gel-barrier tube, green-top (heparin) tube, or lavender-top (EDTA) tube
Collection Instructions
Separate serum or plasma from cells. Transfer specimen to a plastic transport tube.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
See table.
Male (mg/dL) | |
|---|---|
0 to 14 d | 62−91 |
15 d to 11 m | 53−175 |
1 to 5 y | 80−164 |
6 to 12 y | 107−175 |
>12 y | 101−178 |
Female (mg/dL) | |
0 to 14 d | 71−97 |
15 d to 11 m | 53−175 |
1 to 5 y | 80−164 |
6 to 80 y | 116−209 |
>80 y | 114−214 |
Storage Instructions
Maintain specimen at room temperature.
Patient Preparation
Patient must be fasting 12 to 14 hours.
Causes for Rejection
Specimen from nonfasting patient
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 016873 | Apolipoprotein A-1 | 1869-7 | 016873 | Apolipoprotein A-1 | mg/dL | 1869-7 |
| Order Code | 016873 | |||||
| Order Code Name | Apolipoprotein A-1 | |||||
| Order Loinc | 1869-7 | |||||
| Result Code | 016873 | |||||
| Result Code Name | Apolipoprotein A-1 | |||||
| UofM | mg/dL | |||||
| Result LOINC | 1869-7 |