Test Details
Methodology
Multiplex flow immunoassay
Result Turnaround Time
1 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Semiquantitative result of IgG class antibodies
Use
Differential diagnosis of scleroderma (progressive systemic sclerosis)
Custom Additional Information
Scl-70 antibody is seen in 20% of patients with scleroderma, and in some patients with CREST syndrome (calcinosis, Raynaud, esophageal dysfunction, sclerodactyly, telangiectasia). These syndromes are also associated with a high frequency of speckled pattern immunofluorescent antinuclear antibody tests. Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease. In addition, the presence of Scl-70 in Raynaud phenomenon may indicate a poor prognosis.
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
0.0−0.9 AI
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; icterus; lipemia; gross bacterial contamination
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 018705 | Antiscleroderma-70 Antibodies | 27416-7 | 018707 | Antiscleroderma-70 Antibodies | AI | 27416-7 |
| Order Code | 018705 | |||||
| Order Code Name | Antiscleroderma-70 Antibodies | |||||
| Order Loinc | 27416-7 | |||||
| Result Code | 018707 | |||||
| Result Code Name | Antiscleroderma-70 Antibodies | |||||
| UofM | AI | |||||
| Result LOINC | 27416-7 |