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Anti-Jo-1

CPT 86235
Synonyms
  • Polymyositis
  • t-RNA Synthetase

Test Details

Methodology

Multiplex flow immunoassay

Result Turnaround Time

2 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Test Includes

Semiquantitative result of IgG class antibodies

Use

Evaluate patients suspected of having polymyositis, dermatomyositis, or polymyositis-scleroderma overlap syndrome

References

Bernstein RM, Morgan SH, Chapman J, et al. Anti-Jo-1 antibody: A marker for myositis with interstitial lung disease. Br Med J (Clin Res Ed). 1984 Jul 21; 289(6438):151-152. 6430389
Hochberg MC, Feldman D, Stevens MB, Arnett FC, Reichlin M. Antibody to Jo-1 in polymyositis/dermatomyositis: Association with interstitial pulmonary disease. J Rheumatol. 1984 Oct; 11(5):663-665. 6334746

Custom Additional Information

Anti-Jo-1 antibodies are present in approximately 20% to 30% of patients with adult-onset polymyositis syndromes. They are present in >65% of patients with both myositis and interstitial lung disease. In such patients, the presence of anti-Jo-1 antibodies may be predictive of a response to steroid treatment. Testing for ANAs is not adequate for the detection of anti-Jo-1 antibodies.

Specimen Requirements

Specimen

Serum

Volume

0.6 mL

Minimum Volume

0.3 mL

Container

Red-top tube or gel-barrier tube

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Reference Range

0.0−0.9 AI

Storage Instructions

Room temperature

Causes for Rejection

Hemolysis; icterus; lipemia; bacterial contamination

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
161455 Anti-Jo-1 11565-9 161457 Anti-Jo-1 AI 11565-9
Order Code161455
Order Code NameAnti-Jo-1
Order Loinc11565-9
Result Code161457
Result Code NameAnti-Jo-1
UofMAI
Result LOINC11565-9