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For hours, walk-ins and appointments.Synonyms
- ADH
- Arginine Vasopressin
- AVP
- Vasopressin
Test Includes
ADH; osmolality
Expected Turnaround Time
4 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum, refrigerated and plasma, frozen
Volume
1 mL serum and 2 mL plasma
Minimum Volume
0.5 mL serum and 1 mL plasma (Note: This volume does not allow for repeat testing.)
Container
Gel-barrier tube and lavender-top (EDTA) tube
Collection
Draw serum and plasma samples and separate from cells using a refrigerated centrifuge. Transfer separated samples into clearly labeled “plasma” and “serum” plastic transport tubes. Freeze plasma immediately and refrigerate serum. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze plasma immediately. Refrigerate serum.
Patient Preparation
No isotopes administered 24 hours prior to venipuncture
Causes for Rejection
Recently administered isotopes; plasma specimen not received frozen
Test Details
Use
Aid in the diagnosis of urine concentration disorders, especially diabetes insipidus, syndrome of inappropriate ADH (SIADH), psychogenic water intoxication, and syndromes of ectopic ADH production
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
ADH: radioimmunoassay (RIA); osmolality: freezing point depression
Reference Interval
• ADH: 0.0−4.7 pg/mL
• Osmolality:
− Neonates: May be as low as 266 mOsmol/kg
− 0 to 60 years: 275−295 mOsmol/kg
− >60 years: 280−301 mOsmol/kg
Additional Information
ADH, produced in the supraoptic and paraventricular locations of the hypothalamus, acts on the collecting tubules of the kidney to cause increase in permeability to water and urea. ADH release is triggered by a number of both osmotic and nonosmotic stimuli. Measurement of ADH is useful in separating central diabetes insipidus, which is marked by polydipsia and polyuria and is caused by inadequate ADH production from nephrogenic diabetes insipidus caused by the inability of renal tubules to respond to ADH. In SIADH, release of ADH is disproportionate to a low serum osmolality. SIADH results due to a number of conditions such as pulmonary disease, head trauma, and cancer.
References
Cowley AW Jr, Cushman WC, Quillen EW Jr, et al. Vasopressin elevation in essential hypertension and increased responsiveness to sodium intake. Hypertension. 1981; 3(3 Pt 2):I93-100. 7262983
Malvin RL. Possible role of the renin-angiotensin system in the regulation of antidiuretic hormone secretion. Fed Proc. 1971; 30(4):1383-1386. 4326738
Pullan PT, Clappison BH, Johnston CI. Plasma vasopressin and human neurophysins and physiological and pathological states associated with changes in vasopressin secretion. J Clin Endocrinol Metab. 1979; 49(4):580-587. 479348
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 046557 | Antidiuretic Hormone Profile | 010449 | ADH | pg/mL | 3126-0 | |
| 046557 | Antidiuretic Hormone Profile | 002071 | Osmolality | mOsmol/kg | 2692-2 |
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