700180: Amino Acid Profile, Quantitative, Cerebrospinal Fluid

Test Details

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Result Turnaround Time

4 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Amino Acid Test Options

Use

Diagnosis and monitoring of inherited aminoacidurias. Most notably, quantitation of amino acids in CSF is useful in the diagnosis of glycine encephalopathy. CSF samples are most informative when a plasma sample is collected at the same time and ratios of the amino acid concentrations in CSF to plasma are calculated.

Limitations

False-negative results can occur, especially when a patient is affected with a mild or intermittent variant of a disorder, or when clinical condition or dietary treatment causes secondary changes to the profile. Results of amino acid profiling should be interpreted in the context of clinical presentation as well as other laboratory tests.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

References

Bremer HJ, Duran M, Kamerling JP, et al. Disturbances of Amino Acid Metabolism: Clinical Chemistry and Diagnosis. Baltimore, Md: Urban and Schwarzenberg; 1981.

Specimen Requirements

Specimen

Cerebrospinal fluid (CSF), frozen

Volume

0.5 mL

Minimum Volume

0.15 mL (Note: This volume does not allow for repeat testing.)

Container

Plastic transport tube

Collection Instructions

To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Stability Requirements

Temperature	Period
Room temperature	Unstable
Refrigerated	Unstable
Frozen	14 days

Reference Range

See Cerebrospinal Fluid Amino Acid Reference Intervals in the Test Resources pages online.

Storage Instructions

Freeze.

Causes for Rejection

Gross contamination with blood; room temperature or thawed specimen

LOINC® Map

Order Code	Order Code Name	Result Code	Result Code Name	UofM	Result LOINC
700180	Amino Acid Profile, Qn, CSF	700141	Taurine	umol/L	26614-8
700180	Amino Acid Profile, Qn, CSF	700142	Aspartate	umol/L	22655-5
700180	Amino Acid Profile, Qn, CSF	700143	Threonine	umol/L	22643-1
700180	Amino Acid Profile, Qn, CSF	700144	Serine	umol/L	22644-9
700180	Amino Acid Profile, Qn, CSF	700145	Asparagine	umol/L	26603-1
700180	Amino Acid Profile, Qn, CSF	700146	Glutamate	umol/L	22652-2
700180	Amino Acid Profile, Qn, CSF	700147	Glutamine	umol/L	22641-5
700180	Amino Acid Profile, Qn, CSF	700148	Glycine	umol/L	22650-6
700180	Amino Acid Profile, Qn, CSF	700149	Alanine	umol/L	22657-1
700180	Amino Acid Profile, Qn, CSF	700150	Citrulline	umol/L	22654-8
700180	Amino Acid Profile, Qn, CSF	700151	Valine	umol/L	22649-8
700180	Amino Acid Profile, Qn, CSF	700152	Cystine	umol/L	22653-0
700180	Amino Acid Profile, Qn, CSF	700153	Methionine	umol/L	22648-0
700180	Amino Acid Profile, Qn, CSF	700154	Isoleucine	umol/L	22659-7
700180	Amino Acid Profile, Qn, CSF	700155	Leucine	umol/L	9412-8
700180	Amino Acid Profile, Qn, CSF	700156	Tyrosine	umol/L	22642-3
700180	Amino Acid Profile, Qn, CSF	700157	Phenylalanine	umol/L	22646-4
700180	Amino Acid Profile, Qn, CSF	700158	Beta-alanine	umol/L	26589-2
700180	Amino Acid Profile, Qn, CSF	700159	Gamma-aminobutyrate	umol/L	26594-2
700180	Amino Acid Profile, Qn, CSF	700160	Ornithine	umol/L	22647-2
700180	Amino Acid Profile, Qn, CSF	700161	Lysine	umol/L	22651-4
700180	Amino Acid Profile, Qn, CSF	700162	Histidine	umol/L	9453-2
700180	Amino Acid Profile, Qn, CSF	700163	Arginine	umol/L	22656-3
700180	Amino Acid Profile, Qn, CSF	700164	Interpretation		49303-1
700180	Amino Acid Profile, Qn, CSF	700165	Director Review		72486-4
700180	Amino Acid Profile, Qn, CSF	700166	Methodology		49549-9
700180	Amino Acid Profile, Qn, CSF	700471	Disclaimer:		N/A
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700141
Result Code Name	Taurine
UofM	umol/L
Result LOINC	26614-8
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700142
Result Code Name	Aspartate
UofM	umol/L
Result LOINC	22655-5
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700143
Result Code Name	Threonine
UofM	umol/L
Result LOINC	22643-1
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700144
Result Code Name	Serine
UofM	umol/L
Result LOINC	22644-9
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700145
Result Code Name	Asparagine
UofM	umol/L
Result LOINC	26603-1
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700146
Result Code Name	Glutamate
UofM	umol/L
Result LOINC	22652-2
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700147
Result Code Name	Glutamine
UofM	umol/L
Result LOINC	22641-5
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700148
Result Code Name	Glycine
UofM	umol/L
Result LOINC	22650-6
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700149
Result Code Name	Alanine
UofM	umol/L
Result LOINC	22657-1
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700150
Result Code Name	Citrulline
UofM	umol/L
Result LOINC	22654-8
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700151
Result Code Name	Valine
UofM	umol/L
Result LOINC	22649-8
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700152
Result Code Name	Cystine
UofM	umol/L
Result LOINC	22653-0
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700153
Result Code Name	Methionine
UofM	umol/L
Result LOINC	22648-0
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700154
Result Code Name	Isoleucine
UofM	umol/L
Result LOINC	22659-7
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700155
Result Code Name	Leucine
UofM	umol/L
Result LOINC	9412-8
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700156
Result Code Name	Tyrosine
UofM	umol/L
Result LOINC	22642-3
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700157
Result Code Name	Phenylalanine
UofM	umol/L
Result LOINC	22646-4
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700158
Result Code Name	Beta-alanine
UofM	umol/L
Result LOINC	26589-2
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700159
Result Code Name	Gamma-aminobutyrate
UofM	umol/L
Result LOINC	26594-2
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700160
Result Code Name	Ornithine
UofM	umol/L
Result LOINC	22647-2
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700161
Result Code Name	Lysine
UofM	umol/L
Result LOINC	22651-4
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700162
Result Code Name	Histidine
UofM	umol/L
Result LOINC	9453-2
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700163
Result Code Name	Arginine
UofM	umol/L
Result LOINC	22656-3
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700164
Result Code Name	Interpretation
UofM
Result LOINC	49303-1
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700165
Result Code Name	Director Review
UofM
Result LOINC	72486-4
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700166
Result Code Name	Methodology
UofM
Result LOINC	49549-9
Order Code	700180
Order Code Name	Amino Acid Profile, Qn, CSF
Order Loinc
Result Code	700471
Result Code Name	Disclaimer:
UofM
Result LOINC	N/A

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