070228: Acylcarnitine Profile, Quantitative, Plasma

Test Details

Methodology

Flow injection/tandem mass spectrometry

Result Turnaround Time

3 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Use

Used in the diagnosis and monitoring of inherited disorders of fatty acid oxidation and organic acidurias. May be used as a follow-up test to some abnormal newborn screen results.

Limitations

False-negative results can occur with acylcarnitine profiling, especially when the patient is carnitine deficient, is affected with a milder variant of a disorder, or when clinical condition or dietary supplementation causes secondary changes to the profile. Results of acylcarnitine profiling should be interpreted in the context of clinical presentation as well as other laboratory tests, which may include urine organic acid analysis and molecular testing.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

References

Applied Biosystems. Chemoview Instructions. March 15, 2005.

Bennett M. Laboratory Medicine Practice Guidelines−Follow-up Testing for Metabolic Diseases Identified by Expanded Newborn Screening Using Tandem Mass Spectrometry. Washington DC: AACC Press;2009.

Rinaldo P, Cowan TM, Matern D. Acylcarnitine profile analysis. Genet Med. 2008 Feb; 10(2):151-156.18281923

Specimen Requirements

Specimen

Plasma, frozen

Volume

0.5 mL

Minimum Volume

0.1 mL (Note: This volume does not allow for repeat testing)

Container

Green-top (sodium heparin) tube

Collection Instructions

Transfer plasma to a plastic transport tube and freeze. To avoid delays in turnaround time when requesting multiple tests on frozen specimens, please submit separate frozen specimens for each test requested.

Storage Instructions

Frozen: 983 days (2.7 years)

Freeze/Thaw Cycle: Stable x3

Causes for Rejection

Specimen thawed or not frozen; gross hemolysis; specimen type other than frozen plasma

LOINC® Map

Order Code	Order Code Name	Order Loinc	Result Code	Result Code Name	UofM	Result LOINC
070228	Acylcarnitine Profile, Plasma	43433-2	070081	C2	umol/L	30191-1
070228	Acylcarnitine Profile, Plasma	43433-2	070040	C3	umol/L	30551-6
070228	Acylcarnitine Profile, Plasma	43433-2	070041	C3-Dicarboxylic	umol/L	55940-1
070228	Acylcarnitine Profile, Plasma	43433-2	070042	C4	umol/L	51413-3
070228	Acylcarnitine Profile, Plasma	43433-2	070043	C4-Hydroxy	umol/L	39000-5
070228	Acylcarnitine Profile, Plasma	43433-2	070119	C4-Dicarboxylic	umol/L	39010-4
070228	Acylcarnitine Profile, Plasma	43433-2	070044	C5	umol/L	30531-8
070228	Acylcarnitine Profile, Plasma	43433-2	070048	C5:1	umol/L	69573-4
070228	Acylcarnitine Profile, Plasma	43433-2	070049	C5-Hydroxy	umol/L	51412-5
070228	Acylcarnitine Profile, Plasma	43433-2	070051	C5-Dicarboxylic	umol/L	30349-5
070228	Acylcarnitine Profile, Plasma	43433-2	070057	C6	umol/L	30358-6
070228	Acylcarnitine Profile, Plasma	43433-2	070058	C8	umol/L	30540-9
070228	Acylcarnitine Profile, Plasma	43433-2	070059	C10	umol/L	30327-1
070228	Acylcarnitine Profile, Plasma	43433-2	070061	C10:1	umol/L	30328-9
070228	Acylcarnitine Profile, Plasma	43433-2	070062	C10:2	umol/L	53471-9
070228	Acylcarnitine Profile, Plasma	43433-2	070063	C12	umol/L	30331-3
070228	Acylcarnitine Profile, Plasma	43433-2	070064	C14	umol/L	30565-6
070228	Acylcarnitine Profile, Plasma	43433-2	070065	C14:1	umol/L	30566-4
070228	Acylcarnitine Profile, Plasma	43433-2	070066	C14:2	umol/L	30564-9
070228	Acylcarnitine Profile, Plasma	43433-2	070067	C14-Hydroxy	umol/L	30238-0
070228	Acylcarnitine Profile, Plasma	43433-2	070068	C16	umol/L	30356-0
070228	Acylcarnitine Profile, Plasma	43433-2	070069	C16:1	umol/L	30357-8
070228	Acylcarnitine Profile, Plasma	43433-2	070070	C16:1-Hydroxy	umol/L	30235-6
070228	Acylcarnitine Profile, Plasma	43433-2	070071	C16-Hydroxy	umol/L	30234-9
070228	Acylcarnitine Profile, Plasma	43433-2	070072	C18	umol/L	30560-7
070228	Acylcarnitine Profile, Plasma	43433-2	070073	C18:1	umol/L	30542-5
070228	Acylcarnitine Profile, Plasma	43433-2	070074	C18:2	umol/L	30534-2
070228	Acylcarnitine Profile, Plasma	43433-2	070075	C18-Hydroxy	umol/L	35656-8
070228	Acylcarnitine Profile, Plasma	43433-2	070076	C18:1-Hydroxy	umol/L	30312-3
070228	Acylcarnitine Profile, Plasma	43433-2	070077	C18:2-Hydroxy	umol/L	30237-2
070228	Acylcarnitine Profile, Plasma	43433-2	070082	Interpretation		46252-3
070228	Acylcarnitine Profile, Plasma	43433-2	070079	Director Review		72486-4
070228	Acylcarnitine Profile, Plasma	43433-2	070080	Methodology		49549-9
070228	Acylcarnitine Profile, Plasma	43433-2	700471	Disclaimer:		N/A
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070081
Result Code Name	C2
UofM	umol/L
Result LOINC	30191-1
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070040
Result Code Name	C3
UofM	umol/L
Result LOINC	30551-6
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070041
Result Code Name	C3-Dicarboxylic
UofM	umol/L
Result LOINC	55940-1
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070042
Result Code Name	C4
UofM	umol/L
Result LOINC	51413-3
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070043
Result Code Name	C4-Hydroxy
UofM	umol/L
Result LOINC	39000-5
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070119
Result Code Name	C4-Dicarboxylic
UofM	umol/L
Result LOINC	39010-4
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070044
Result Code Name	C5
UofM	umol/L
Result LOINC	30531-8
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070048
Result Code Name	C5:1
UofM	umol/L
Result LOINC	69573-4
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070049
Result Code Name	C5-Hydroxy
UofM	umol/L
Result LOINC	51412-5
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070051
Result Code Name	C5-Dicarboxylic
UofM	umol/L
Result LOINC	30349-5
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070057
Result Code Name	C6
UofM	umol/L
Result LOINC	30358-6
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070058
Result Code Name	C8
UofM	umol/L
Result LOINC	30540-9
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070059
Result Code Name	C10
UofM	umol/L
Result LOINC	30327-1
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070061
Result Code Name	C10:1
UofM	umol/L
Result LOINC	30328-9
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070062
Result Code Name	C10:2
UofM	umol/L
Result LOINC	53471-9
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070063
Result Code Name	C12
UofM	umol/L
Result LOINC	30331-3
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070064
Result Code Name	C14
UofM	umol/L
Result LOINC	30565-6
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070065
Result Code Name	C14:1
UofM	umol/L
Result LOINC	30566-4
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070066
Result Code Name	C14:2
UofM	umol/L
Result LOINC	30564-9
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070067
Result Code Name	C14-Hydroxy
UofM	umol/L
Result LOINC	30238-0
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070068
Result Code Name	C16
UofM	umol/L
Result LOINC	30356-0
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070069
Result Code Name	C16:1
UofM	umol/L
Result LOINC	30357-8
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070070
Result Code Name	C16:1-Hydroxy
UofM	umol/L
Result LOINC	30235-6
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070071
Result Code Name	C16-Hydroxy
UofM	umol/L
Result LOINC	30234-9
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070072
Result Code Name	C18
UofM	umol/L
Result LOINC	30560-7
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070073
Result Code Name	C18:1
UofM	umol/L
Result LOINC	30542-5
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070074
Result Code Name	C18:2
UofM	umol/L
Result LOINC	30534-2
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070075
Result Code Name	C18-Hydroxy
UofM	umol/L
Result LOINC	35656-8
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070076
Result Code Name	C18:1-Hydroxy
UofM	umol/L
Result LOINC	30312-3
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070077
Result Code Name	C18:2-Hydroxy
UofM	umol/L
Result LOINC	30237-2
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070082
Result Code Name	Interpretation
UofM
Result LOINC	46252-3
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070079
Result Code Name	Director Review
UofM
Result LOINC	72486-4
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	070080
Result Code Name	Methodology
UofM
Result LOINC	49549-9
Order Code	070228
Order Code Name	Acylcarnitine Profile, Plasma
Order Loinc	43433-2
Result Code	700471
Result Code Name	Disclaimer:
UofM
Result LOINC	N/A

Managing Your Health

Diseases & Therapeutic Areas

Treatment Modalities & Methods

Scientific Lab Disciplines

Labs

Industries