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COVID-19 Induced Thrombotic Microangiopathy Profile

CPT 83615; 85240; 85246; 85379; 85397; 86162

Test Details

Methodology

See individual test components.

Result Turnaround Time

2 - 4 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Test Includes

ADAMTS13 Activity; Complement, Total (CH50); D-Dimer; Factor VIII Activity; Lactic Acid Dehydrogenase (LD); von Willebrand Profile

Use

Assessment of patients at high risk of COVID-19-associated thrombotic microangiopathy.

Limitations

For von Willebrand Factor (vWF) Antigen [086280]: This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approvedby the Food and Drug Administration.

References

Doevelaar A, Bachmann M, Hölzer B, et al. COVID-19 is associated with relative ADAMTS13 deficiency and VWF multimer formation resembling TTP. medRxiv preprint posted August 25, 2020. doi.org/10.1101/2020.08.23.20177824.
Goshua G, Pine AB, Meizlish ML, et al. Endoteliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Lancet Haematol. 2020 Aug;7(8):e575-e582.32619411
Jodele S, Fukuda T, Vinks A, et al. Eculizumab Therapy in Children with Severe Hematopoietic Stem Cell Transplantation-Associated Thrombotic Microangiopathy. Biol Blood Marrow Transplant. 2014 Apr;20(4):518-525.24370861
Mancini I, Baronciani L, Artoni A, et al. The ADAMTS13-von Willebrand factor axis in COVID-19 patients. J Thromb Haemost. 2021 Feb;19(2):513-521.33230904

Specimen Requirements

Specimen

Serum and plasma

Volume

2 mL serum and 4.5 mL plasma (sodium citrate)

Minimum Volume

1 mL serum and 3 mL plasma (sodium citrate) (Note: This volume does not allow for repeat testing.)

Container

Gel-barrier tube and blue-top (sodium citrate) tube

Collection Instructions

Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples. When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge and carefully remove the plasma using a plastic transfer pipette, being careful not to disturb the cells. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze plasma within four hours of blood collection and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit seperate frozen specimens for each test requested.

Storage Instructions

Frozen: Serum and plasma

Room temperature: Serum

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164044 COVID-19 Microangiopathy Panel 001941 Complement, Total (CH50) U/mL 4532-8
164044 COVID-19 Microangiopathy Panel 001115 LDH IU/L 14804-9
164044 COVID-19 Microangiopathy Panel 086264 Factor VIII Activity % 3209-4
164044 COVID-19 Microangiopathy Panel 086280 von Willebrand Factor (vWF) Ag % 27816-8
164044 COVID-19 Microangiopathy Panel 115206 D-Dimer mg/L FEU 48065-7
164044 COVID-19 Microangiopathy Panel 117928 ADAMTS13 Activity % 53622-7
164044 COVID-19 Microangiopathy Panel 164045 Induced Thrombotic Panel N/A
Order Code164044
Order Code NameCOVID-19 Microangiopathy Panel
Order Loinc
Result Code001941
Result Code NameComplement, Total (CH50)
UofMU/mL
Result LOINC4532-8
Order Code164044
Order Code NameCOVID-19 Microangiopathy Panel
Order Loinc
Result Code001115
Result Code NameLDH
UofMIU/L
Result LOINC14804-9
Order Code164044
Order Code NameCOVID-19 Microangiopathy Panel
Order Loinc
Result Code086264
Result Code NameFactor VIII Activity
UofM%
Result LOINC3209-4
Order Code164044
Order Code NameCOVID-19 Microangiopathy Panel
Order Loinc
Result Code086280
Result Code Namevon Willebrand Factor (vWF) Ag
UofM%
Result LOINC27816-8
Order Code164044
Order Code NameCOVID-19 Microangiopathy Panel
Order Loinc
Result Code115206
Result Code NameD-Dimer
UofMmg/L FEU
Result LOINC48065-7
Order Code164044
Order Code NameCOVID-19 Microangiopathy Panel
Order Loinc
Result Code117928
Result Code NameADAMTS13 Activity
UofM%
Result LOINC53622-7
Order Code164044
Order Code NameCOVID-19 Microangiopathy Panel
Order Loinc
Result Code164045
Result Code NameInduced Thrombotic Panel
UofM
Result LOINCN/A
Reflex Table for ADAMTS13 Activity
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117917 Comment: 117917 Comment: N/A
Reflex 1
Order Code117917
Order NameComment:
Result Code117917
Result NameComment:
UofM
Result LOINCN/A
Reflex Table for ADAMTS13 Activity
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117931 Comment 117931 Comment N/A
Reflex 1
Order Code117931
Order NameComment
Result Code117931
Result NameComment
UofM
Result LOINCN/A