Labcorp has recently completed full-service execution of a Phase I multiple ascending dose (MAD) study in Parkinson's disease (PD) patients. This case study presented a typical set of challenges encountered when executing PD studies, as well as unique challenges pertaining to the specifics of the protocol. Our successful execution culminated from the outstanding performance of a high-performing expert team, along with tested processes and tactics that were put in place to offer appropriate solutions to the many challenges that were encountered. Additionally, our team was able to build and nurture strong relationships with top-tier sites, which not only have the correct set of capabilities and appropriate patient population and recruitment expectations, but were also able to accommodate and deliver on all procedures required of such a demanding MAD study.