Historical control data of spontaneous tumors in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice

SOT 2025 -- Short-term (6-month) carcinogenicity studies using genetically engineered animals have been demonstrated to be a reliable alternative model to long-term conventional carcinogenicity studies. CByB6F1-Tg(HRAS)2Jic (rasH2) is a genetically engineered hemizygous transgenic mouse containing the human c-Ha-ras proto-oncogene (c-Ha-ras) and is approved by regulatory agencies for carcinogenicity assessment. Comparative data was collected from the historical data for mortality, body weights, and spontaneous tumor incidences in vehicle control article (vehicle) administered CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice from 6-month carcinogenicity studies and were analysed from the data compiled from multiple Labcorp Safety Assessment facilities from 2014 to 2023.