De-risking the performance of OECD 443 studies through the conduct of robust dose range finding studies

A recent European Chemicals Agency (ECHA) review project regarding the design of the OECD 443 (Extended One-Generation Reproductive Toxicity Study or EOGRTS) aimed to assess the performance of the study in terms of study design, conduct and findings to determine if the study design currently prescribed gives sufficient information for regulatory hazard classification.