Find more information about our celiac disease testing
 

Current Celiac Testing Options

We help you diagnose or rule out celiac disease through our comprehensive menu of celiac antibody and genetic (HLA) tests. We also provide a quantitative test for gluten in stool samples to help monitor adherence to a gluten-free diet.

Multiple celiac profile and individual test choices are available to fit the needs of patients and family members, whether they are on a regular or gluten-free diet. For children younger than 2 years of age, the antibody profile recommended is 164010.5

Our Celiac HLA testing is comprehensive, reporting on DQ2, DQ8, and half DQ2, in addition to genetic risk.

The Celiac HLA Association Reflex to Antibodies profile provides both genetic and antibody results in one test order.

For patients on diets containing gluten
 

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For patients on a gluten-free diet 
 

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The benefits of genetic testing options for celiac disease

  • Genetic results are unaffected by a gluten-free diet
  • Celiac genetic testing is only needed once in a lifetime
  • A positive result (HLA DQ2, DQ8, or half DQ2) reveals genetic predisposition to celiac disease
  • A negative result essentially excludes celiac disease

Celiac genetic testing is most useful in the following circumstances5,7:

  • For patients (symptomatic or asymptomatic) with a confirmed case of celiac disease in a first-degree relative – for celiac risk assessment
  • To examine suspicion of celiac disease in patients on a gluten free diet – to rule out celiac disease or confirm predisposition
  • To rule out celiac disease in patients with ambiguous antibody or small bowel biopsy results or discrepancy between those results

We have two options for celiac genetic testing: HLA DQ alone (test code: 167082) HLA DQ with reflex to celiac antibodies: If celiac HLA results are positive, testing reflexes to celiac antibodies (test code: 164019) Genetic counseling services are available at 800-533-1037 (revise number)


References:

  1. Hujoel IA, Reilly NR, Rubio-Tapia A. Celiac Disease: Clinical Features and Diagnosis. Gastroenterol Clin North Am 2019 Mar;48(1):19-17.
  2. Choung RS, Unalp-Arida A, Ruhl CE, Brantner TL, Everhart JE, Murray JA. Less hidden celiac disease but increased gluten avoidance in the USA: Findings from the National Health and Nutrition Examination Surveys from 2009 – 2014. Mayo Clin Proc 2016 Dec 5:S0025-6196(16)30634. doi: 10.1016/j.mayocp.2016.10.012. Online ahead of print.
  3. Taylor AK, Lebwohl B, Snyder CL, Green PHR. Celiac Disease. In: Adam MP, Feldman J, Mirzaa GM, et al., eds. GeneReviews®. Seattle (WA): University of Washington, Seattle; July 3, 2008.
  4. Nellikkal SS, Hafed Y, Larsen JJ, Murray JA, Absah I. High prevalence of celiac disease among screened first-degree relatives. Mayo Clin Proc. 2019 Sep;94(9):1807-1813.
  5. Rubio-Tapia A, Hill ID, Samrad C, Kelly CP, Greer KB, Limketkai BN, Lebwohl B. American College of Gastroenterology Guidelines Update: Diagnosis and management of celiac disease. Am J Gastroenterol. 2023 Jan 1;118(1):59-76.
  6. Hill ID, Fasano A, Guandalini S, Hoffenberg E, Levy J, Reilly N, Verma R. NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-Related Disorders. JPGN. 2016;63:156-165.
  7. Brown K, Guandalini A, Semrad C and Kupfer SS. A clinician’s guide to celiac disease HLA genetics. Am J Gastroenterol. 2019; Oct;114(10):1587- 1592.