Correlation of Anti-DFS70 Autoantibodies by ELISA with HEp-2 Cells DFS Pattern by IFA

Anti-DFS70 antibodies are associated with a dense-fine speckled (DFS) pattern by IFA while their clinical associations remain an immunological enigma. This study provides supporting evidence of the significant association between the DFS pattern by IFA and anti-DFS70 antibodies by ELISA and offers a potential algorithm to triage patients to exclude systemic autoimmune rheumatic diseases/ANA-associated rheumatic diseases (SARD/AARD).