IAT Congress 2025 -- To support development of compounds requiring a constant exposure level, toxicology studies can be conducted with a continuous intravenous infusion method of administration, using surgically prepared animals, for up to 24 hours a day. Until recently, the rat has been the species of choice for such testing, but an alternative species can be the mouse and, therefore, a mouse vascular infusion model was developed for repeated dosing/long-term toxicity infusion studies. Typically, this would involve adult animals; however, based on a requirement to support use of drugs in the paediatric population, there is a potential need to dose animals of juvenile age. This poster will present results showing how vascular continuous infusion in mice with tail-cuff exteriorization has been developed and refined, along with the successful use of two other infusion models in juvenile-age mice (tail cuff and vascular access button exteriorisation). 

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